Member database | SFLD |
SFLD type | family |
Short name | Main.4:_Theta-like |
Description
Cytosolic GSTs that include proteins with "Theta" Swiss-Prot family annotations. Proteins in this subgroup are known to catalyze the following reaction types: conjugate addition, epoxide ring opening, hydrolytic dehalogenation, nucleophilic addition, nucleophilic aromatic substitution, nucleophilic substitution (SN2), peroxidase, and thiolysis reactions. For example, SFLD protein 55995 (UniProt accn P20432) has experimentally-confirmed conjugate addition activity with ethacrynic acid; nucleophilic aromatic substitution activity with CDNB and DCNB (dichloronitrobenzene); and peroxidase activity with 4-hydroperoxy-2-nonenal. It additionally has DDT-dehydrochlorinase activity with the synthetic pesticide and environmental pollutant DDT.