Member database | SMART |
SMART type | domain |
Short name | S_TK_X |
Description Imported from IPR000961
* Serine/threonine-protein kinases
* Tyrosine-protein kinases
* Dual specificity protein kinases (e.g. MEK -phosphorylates both Thr and Tyr on target proteins)
References Imported from IPR000961
1.The protein kinase complement of the human genome. Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S. Science 298, 1912-34, (2002). View articlePMID: 12471243
2.Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm. Newton AC. Biochem. J. 370, 361-71, (2003). View articlePMID: 12495431
3.AGC protein kinase phosphorylation and protein kinase C. Parker PJ, Parkinson SJ. Biochem. Soc. Trans. 29, 860-3, (2001). View articlePMID: 11709088
4.PDK1, the master regulator of AGC kinase signal transduction. Mora A, Komander D, van Aalten DM, Alessi DR. Semin. Cell Dev. Biol. 15, 161-70, (2004). View articlePMID: 15209375
5.Crystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-PNP. Yang J, Cron P, Good VM, Thompson V, Hemmings BA, Barford D. Nat. Struct. Biol. 9, 940-4, (2002). View articlePMID: 12434148
6.The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. Hanks SK, Quinn AM, Hunter T. Science 241, 42-52, (1988). View articlePMID: 3291115
7.Evolution of protein kinase signaling from yeast to man. Manning G, Plowman GD, Hunter T, Sudarsanam S. Trends Biochem. Sci. 27, 514-20, (2002). View articlePMID: 12368087
8.High-throughput structural biology in drug discovery: protein kinases. Stout TJ, Foster PG, Matthews DJ. Curr. Pharm. Des. 10, 1069-82, (2004). View articlePMID: 15078142
9.Creating chemical diversity to target protein kinases. Li B, Liu Y, Uno T, Gray N. Comb. Chem. High Throughput Screen. 7, 453-72, (2004). View articlePMID: 15320712