Member database | SMART |
SMART type | domain |
Short name | C2 |
Description
Ca2+-binding motif present in phospholipases, protein kinases C, and synaptotagmins (among others). Some do not appear to contain Ca2+-binding sites. Particular C2s appear to bind phospholipids, inositol polyphosphates, and intracellular proteins. Unusual occurrence in perforin. Synaptotagmin and PLC C2s are permuted in sequence with respect to N- and C-terminal beta strands. SMART detects C2 domains using one or both of two profiles.
Integrated to
External Links
Representative structure
2bwq: Crystal Structure of the RIM2 C2A-domain at 1.4 angstrom Resolution