Member database | SMART |
SMART type | domain |
Short name | TIR |
Description Imported from IPR000157
References Imported from IPR000157
1.TLR6: A novel member of an expanding toll-like receptor family. Takeuchi O, Kawai T, Sanjo H, Copeland NG, Gilbert DJ, Jenkins NA, Takeda K, Akira S. Gene 231, 59-65, (1999). View articlePMID: 10231569
2.IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. Muzio M, Ni J, Feng P, Dixit VM. Science 278, 1612-5, (1997). View articlePMID: 9374458
3.Toll signaling pathways in the innate immune response. Anderson KV. Curr. Opin. Immunol. 12, 13-9, (2000). View articlePMID: 10679407
4.Identification of two major sites in the type I interleukin-1 receptor cytoplasmic region responsible for coupling to pro-inflammatory signaling pathways. Slack JL, Schooley K, Bonnert TP, Mitcham JL, Qwarnstrom EE, Sims JE, Dower SK. J. Biol. Chem. 275, 4670-8, (2000). View articlePMID: 10671496
5.T1/ST2 signaling establishes it as a member of an expanding interleukin-1 receptor family. Mitcham JL, Parnet P, Bonnert TP, Garka KE, Gerhart MJ, Slack JL, Gayle MA, Dower SK, Sims JE. J. Biol. Chem. 271, 5777-83, (1996). View articlePMID: 8621445
6.Structural basis for signal transduction by the Toll/interleukin-1 receptor domains. Xu Y, Tao X, Shen B, Horng T, Medzhitov R, Manley JL, Tong L. Nature 408, 111-5, (2000). View articlePMID: 11081518
7.NAD<sup>+</sup> cleavage activity by animal and plant TIR domains in cell death pathways. Horsefield S, Burdett H, Zhang X, Manik MK, Shi Y, Chen J, Qi T, Gilley J, Lai JS, Rank MX, Casey LW, Gu W, Ericsson DJ, Foley G, Hughes RO, Bosanac T, von Itzstein M, Rathjen JP, Nanson JD, Boden M, Dry IB, Williams SJ, Staskawicz BJ, Coleman MP, Ve T, Dodds PN, Kobe B. Science 365, 793-799, (2019). PMID: 31439792
8.TIR domains of plant immune receptors are NAD<sup>+</sup>-cleaving enzymes that promote cell death. Wan L, Essuman K, Anderson RG, Sasaki Y, Monteiro F, Chung EH, Osborne Nishimura E, DiAntonio A, Milbrandt J, Dangl JL, Nishimura MT. Science 365, 799-803, (2019). PMID: 31439793
9.Plant disease-resistance proteins and the gene-for-gene concept. Van der Biezen EA, Jones JD. Trends Biochem. Sci. 23, 454-6, (1998). View articlePMID: 9868361