SM00490

helicase superfamily c-terminal domain

SMART entry
Member databaseSMART
SMART typedomain
Short nameHELICc

Description
Imported from IPR001650

Helicases have been classified in 5 superfamilies (SF1-SF5). For the two largest groups, commonly referred to as SF1 and SF2, a total of seven characteristic motifs has been identified
[2]
. These two superfamilies encompass a large number of DNA and RNA helicases from archaea, eubacteria, eukaryotes and viruses.

This entry represents the C-terminal domain found in proteins belonging to the helicase superfamilies 1 and 2. Included in this group is the eukaryotic translation initiation factor 4A (eIF4A), a member of the DEA(D/H)-box RNA helicase family. The structure of the carboxyl-terminal domain of eIF4A has been determined; it has a parallel α-β topology that superimposes, with minor variations, on the structures and conserved motifs of the equivalent domain in other, distantly related helicases
[1]
.

References
Imported from IPR001650

1.Crystal structure of yeast initiation factor 4A, a DEAD-box RNA helicase. Caruthers JM, Johnson ER, McKay DB. Proc. Natl. Acad. Sci. U.S.A. 97, 13080-5, (2000). View articlePMID: 11087862

2.Two related superfamilies of putative helicases involved in replication, recombination, repair and expression of DNA and RNA genomes. Gorbalenya AE, Koonin EV, Donchenko AP, Blinov VM. Nucleic Acids Res. 17, 4713-30, (1989). View articlePMID: 2546125

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