SM00602

VPS10

SMART entry
Member databaseSMART
SMART typedomain
Short nameVPS10

Description
Imported from IPR006581

Yeast Vps10p is a receptor for sorting and transport of the soluble vacuolar hydrolase carboxypeptidase Y to the lysosome-like vacuole
[3]
. In mammalian cells, proteins containing this domain are involved in the transport of lipoproteins and sorting of endosomal proteins. They may also act as receptors for some neuropeptides.

The N terminus of murine brain SorCS contains two putative cleavage sites for the convertase furin which mark the beginning of the VPS10 domain, which is followed by a module of imperfect leucine-rich repeats and a transmembrane domain. The short intracellular C terminus contains consensus signals for rapid internalization. The identified putative binding motifs for SH2 and SH3 domains are unique in the family of VPS10 domain receptors. SorCS is predominantly expressed in brain, but also in heart, liver, and kidney. SorCS transcripts detected by in situ hybridization in the murine central nervous system point to a neuronal expression
[1, 2]
.

References
Imported from IPR006581

1.Identification and characterization of SorCS, a third member of a novel receptor family. Hermey G, Riedel IB, Hampe W, Schaller HC, Hermans-Borgmeyer I. Biochem. Biophys. Res. Commun. 266, 347-51, (1999). View articlePMID: 10600506

2.Vps9p is a guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport. Hama H, Tall GG, Horazdovsky BF. J. Biol. Chem. 274, 15284-91, (1999). View articlePMID: 10329739

3.The yeast Vps10p cytoplasmic tail mediates lysosomal sorting in mammalian cells and interacts with human GGAs. Dennes A, Madsen P, Nielsen MS, Petersen CM, Pohlmann R. J. Biol. Chem. 277, 12288-93, (2002). View articlePMID: 11801606

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