SM00663

RNA polymerase I subunit A N-terminus

SMART entry
Member databaseSMART
SMART typedomain
Short nameRPOLA_N

Description
Imported from IPR006592

The task of transcribing nuclear genes is shared between three RNA polymerases in eukaryotes: RNA polymerase (pol) I synthesizes the large rRNA, pol II synthesizes mRNA and pol III synthesizes tRNA and 5S rRNA
[1]
. Pol I transcription is localised to discrete sites called nucleoli; these can be likened to ribosome factories, in which rRNA is synthesised by pol I in the fibrillar centres and then processed and assembled into ribosomes in the surrounding granular regions
[2]
. Prokaryotes, in contrast, posses a single RNA polymerase, with transcription being controlled by the particular signam factor interacting with the catalytic core.

This entry describes an N-terminal conserved region which can be found in the largest subunits of prokaryoptic and eukaryotic RNA polymerases.

References
Imported from IPR006592

1.Survey and summary: transcription by RNA polymerases I and III. Paule MR, White RJ. Nucleic Acids Res. 28, 1283-98, (2000). View articlePMID: 10684922

2.The nucleolus. Shaw PJ, Jordan EG. Annu. Rev. Cell Dev. Biol. 11, 93-121, (1995). View articlePMID: 8689574

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