Member database | SMART |
SMART type | domain |
Short name | calpain_III |
Description Imported from IPR022683
- * A 19-amino acid NH2-terminal sequence;
* Active site domain IIa;
* Active site domain IIb. Domain 2 shows low levels of sequence similarity to papain; although the catalytic His has not been located by biochemical means, it is likely that calpain and papain are related
* Domain III;
* An 18-amino acid extended sequence linking domain III to domain IV;
* Domain IV, which resembles the penta EF-hand family of polypeptides, binds calcium and regulates activity
References Imported from IPR022683
1.How calpain is activated by calcium. Khorchid A, Ikura M. Nat. Struct. Biol. 9, 239-41, (2002). View articlePMID: 11914728
2.Tandemly reiterated negative enhancer-like elements regulate transcription of a human gene for the large subunit of calcium-dependent protease. Hata A, Ohno S, Akita Y, Suzuki K. J. Biol. Chem. 264, 6404-11, (1989). View articlePMID: 2539381
3.Evolutionary lines of cysteine peptidases. Barrett AJ, Rawlings ND. Biol. Chem. 382, 727-33, (2001). View articlePMID: 11517925
4.The structure of sortase B, a cysteine transpeptidase that tethers surface protein to the Staphylococcus aureus cell wall. Zong Y, Mazmanian SK, Schneewind O, Narayana SV. Structure 12, 105-12, (2004). View articlePMID: 14725770
5.Calpains: an elaborate proteolytic system. Ono Y, Sorimachi H. Biochim. Biophys. Acta 1824, 224-36, (2012). View articlePMID: 21864727
6.The structure of calpain. Sorimachi H, Suzuki K. J. Biochem. 129, 653-64, (2001). View articlePMID: 11328585
7.Identification of the active site of legumain links it to caspases, clostripain and gingipains in a new clan of cysteine endopeptidases. Chen JM, Rawlings ND, Stevens RA, Barrett AJ. FEBS Lett. 441, 361-5, (1998). View articlePMID: 9891971
8.Structural basis for possible calcium-induced activation mechanisms of calpains. Reverter D, Strobl S, Fernandez-Catalan C, Sorimachi H, Suzuki K, Bode W. Biol. Chem. 382, 753-66, (2001). View articlePMID: 11517928
9.Families of cysteine peptidases. Rawlings ND, Barrett AJ. Meth. Enzymol. 244, 461-86, (1994). View articlePMID: 7845226
10.The calpain system. Goll DE, Thompson VF, Li H, Wei W, Cong J. Physiol. Rev. 83, 731-801, (2003). View articlePMID: 12843408
11.L-trans-Epoxysuccinyl-leucylamido(4-guanidino)butane (E-64) and its analogues as inhibitors of cysteine proteinases including cathepsins B, H and L. Barrett AJ, Kembhavi AA, Brown MA, Kirschke H, Knight CG, Tamai M, Hanada K. Biochem. J. 201, 189-98, (1982). PMID: 7044372
12.Structure and physiological function of calpains. Sorimachi H, Ishiura S, Suzuki K. Biochem. J. 328 ( Pt 3), 721-32, (1997). View articlePMID: 9396712
13.Molecular cloning of a novel mammalian calcium-dependent protease distinct from both m- and mu-types. Specific expression of the mRNA in skeletal muscle. Sorimachi H, Imajoh-Ohmi S, Emori Y, Kawasaki H, Ohno S, Minami Y, Suzuki K. J. Biol. Chem. 264, 20106-11, (1989). View articlePMID: 2555341