Member database | SMART |
SMART type | domain |
Short name | HIRAN |
Description
The HIRAN protein (HIP116, Rad5p N-terminal) is found in the N-terminal regions of the SWI2/SNF2 proteins typified by HIP116 and Rad5p. HIRAN is found as a standalone protein in several bacteria and prophages, or fused to other catalytic domains, such as a nuclease of the restriction endonuclease fold and TDP1-like DNA phosphoesterases, in the eukaryotes PUBMED:16627993. It has been predicted that this protein functions as a DNA-binding domain that probably recognises features associated with damaged DNA or stalled replication forks PUBMED:16627993
Integrated to
External Links
Representative structure
4xzf: Crystal structure of HIRAN domain of human HLTF in complex with DNA