Member database | SMART |
SMART type | domain |
Short name | LeuA_dimer |
Description
This is the C-terminal regulatory (R) domain of alpha-isopropylmalate synthase, which catalyses the first committed step in the leucine biosynthetic pathway PUBMED:15159544. This domain, is an internally duplicated structure with a novel fold PUBMED:15159544. It comprises two similar units that are arranged such that the two -helices pack together in the centre, crossing at an angle of 34 degrees, sandwiched between the two three-stranded, antiparallel beta-sheets. The overall domain is thus constructed as a beta-alpha-beta three-layer sandwich PUBMED:15159544.
Integrated to
External Links
Representative structure
3f6g: Crystal structure of the regulatory domain of LiCMS in complexed with isoleucine - type II