SSF143243

Nqo5-like

SUPERFAMILY entry
Member databaseSUPERFAMILY
SUPERFAMILY typehomologous superfamily

Description
Imported from IPR037232

Respiratory-chain NADH dehydrogenase (
1.6.5.3
) (also known as complex I or NADH-ubiquinone oxidoreductase) is an oligomeric enzymatic complex located in the inner mitochondrial membrane which also seems to exist in the chloroplast and in cyanobacteria (as a NADH-plastoquinone oxidoreductase). Among the 25 to 30 polypeptide subunits of this bioenergetic enzyme complex there is one with a molecular weight of 30 Kd (in mammals) which has been found to be
[2]
:


 * Nuclear encoded, as a precursor form with a transit peptide in mammals, and in Neurospora crassa.
 * Mitochondrial encoded in Paramecium (protein P1), and in the slime mold Dictyostelium discoideum (ORF 209).
 * Chloroplast encoded in various higher plants (ORF 159).


It is also present in bacteria:


 * In the cyanobacteria Synechocystis strain PCC 6803 (gene ndhJ).
 * Subunit C of Escherichia coli NADH-ubiquinone oxidoreductase (gene nuoC).
 * Subunit Nqo5 of Paracoccus denitrificans NADH-ubiquinone oxidoreductase. Nqo5 composes the hydrogenase-like module together with the Nqo4, Nqo6, and Nqo9 subunits. Homologous proteins of the Nqo5 subunit are also contained in membrane-bound multisubunit hydrogenases, while soluble-type hydrogenases are not. This subunit is essential in complex I assembly
[1]
.

References
Imported from IPR037232

1.Characterization of the Nqo5 subunit of bacterial complex I in the isolated state. Hanazono Y, Takeda K, Miki K. FEBS Open Bio 6, 687-95, (2016). PMID: 27398308

2.The respiratory-chain NADH dehydrogenase (complex I) of mitochondria. Weiss H, Friedrich T, Hofhaus G, Preis D. Eur. J. Biochem. 197, 563-76, (1991). View articlePMID: 2029890

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