SSF143492

Prenyltransferase-like

SUPERFAMILY entry
Member databaseSUPERFAMILY
SUPERFAMILY typehomologous superfamily

Description
Imported from IPR036239

This superfamily is characterized by a barrel fold consisting of a cylindrical β-sheet comprising anti-parallel β-strands arranged around a central solvent-filled core
[1]
. This fold can be found in:


 * Aromatic prenyltransferases NovQ from Streptomyces niveus and CloQ from Streptomyces roseochromogenes. They catalyse the transfer of a dimethylallyl group to 4-hydroxyphenylpyruvate to produce the ring A structure in the novobiocin and clorobiocin biosynthesis pathways, respectively
[6, 2]
.
 * Flaviolin linalyltransferase from Streptomyces cinnamonensis. It is involved in the biosynthesis of furanonaphthoquinone I (FNQ I). It catalyses C- and O-prenylations of different phenolic substrates
[5, 3]
.
 * 5,10-dihydrophenazine-1-carboxylate 9-dimethylallyltransferase from Streptomyces anulatus. It is involved in the biosynthesis of prenylated phenazines. It catalyses the transfer of a dimethylallyl moiety to C-9 of 5,10-dihydrophenazine 1-carboxylate (dihydro-PCA). It is specific for both dimethylallyl diphosphate and dihydro-PCA
[4]
.

References
Imported from IPR036239

1.Structural basis for the promiscuous biosynthetic prenylation of aromatic natural products. Kuzuyama T, Noel JP, Richard SB. Nature 435, 983-7, (2005). View articlePMID: 15959519

2.CloQ, a prenyltransferase involved in clorobiocin biosynthesis. Pojer F, Wemakor E, Kammerer B, Chen H, Walsh CT, Li SM, Heide L. Proc. Natl. Acad. Sci. U.S.A. 100, 2316-21, (2003). View articlePMID: 12618544

3.A soluble, magnesium-independent prenyltransferase catalyzes reverse and regular C-prenylations and O-prenylations of aromatic substrates. Haagen Y, Unsold I, Westrich L, Gust B, Richard SB, Noel JP, Heide L. FEBS Lett. 581, 2889-93, (2007). View articlePMID: 17543953

4.Aromatic prenylation in phenazine biosynthesis: dihydrophenazine-1-carboxylate dimethylallyltransferase from Streptomyces anulatus. Saleh O, Gust B, Boll B, Fiedler HP, Heide L. J. Biol. Chem. 284, 14439-47, (2009). View articlePMID: 19339241

5.A gene cluster for prenylated naphthoquinone and prenylated phenazine biosynthesis in Streptomyces cinnamonensis DSM 1042. Haagen Y, Gluck K, Fay K, Kammerer B, Gust B, Heide L. Chembiochem 7, 2016-27, (2006). View articlePMID: 17103476

6.NovQ is a prenyltransferase capable of catalyzing the addition of a dimethylallyl group to both phenylpropanoids and flavonoids. Ozaki T, Mishima S, Nishiyama M, Kuzuyama T. J. Antibiot. 62, 385-92, (2009). View articlePMID: 19557032

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