SSF47005

Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex

SUPERFAMILY entry
Member databaseSUPERFAMILY
SUPERFAMILY typehomologous superfamily

Description
Imported from IPR036625

A small domain of the E2 subunit of 2-oxo-acid dehydrogenases that is responsible for the binding of the E3 subunit. Proteins containing this domain include the branched-chain alpha-keto acid dehydrogenase complex of bacteria, which catalyses the overall conversion of alpha-keto acids to acyl-CoA and carbon dioxide; and the E3 binding protein of eukaryotic pyruvate dehydrogenase
[1]
.

The structure of the E3-binding domain has three helices with a close bundle fold and right-handed twist going up-and-down
[2]
. This structure arrangement is also found at the C-terminal of Nucleoid-associated protein Lsr2 and Protein Ku, in which it is a DNA-binding domain
[3]
.

References
Imported from IPR036625

1.Protein-protein interactions in the pyruvate dehydrogenase multienzyme complex: dihydrolipoamide dehydrogenase complexed with the binding domain of dihydrolipoamide acetyltransferase. Mande SS, Sarfaty S, Allen MD, Perham RN, Hol WG. Structure 4, 277-86, (1996). View articlePMID: 8805537

2.The folding mechanism of BBL: Plasticity of transition-state structure observed within an ultrafast folding protein family. Neuweiler H, Sharpe TD, Rutherford TJ, Johnson CM, Allen MD, Ferguson N, Fersht AR. J. Mol. Biol. 390, 1060-73, (2009). PMID: 19445954

3.Lsr2 is a nucleoid-associated protein that targets AT-rich sequences and virulence genes in Mycobacterium tuberculosis. Gordon BR, Li Y, Wang L, Sintsova A, van Bakel H, Tian S, Navarre WW, Xia B, Liu J. Proc. Natl. Acad. Sci. U.S.A. 107, 5154-9, (2010). PMID: 20133735

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