SSF47769

SAM/Pointed domain

SUPERFAMILY entry
Member databaseSUPERFAMILY
SUPERFAMILY typehomologous superfamily

Description
Imported from IPR013761

Sterile alpha motif (SAM) domains are known to be involved in diverse protein-protein interactions, associating with both SAM-containing and non-SAM-containing proteins pathway
[1]
. SAM domains exhibit a conserved structure, consisting of a 4-5-helical bundle of two orthogonally packed α-hairpins. However SAM domains display a diversity of function, being involved in interactions with proteins, DNA and RNA
[2]
. The name sterile alpha motif arose from its presence in proteins that are essential for yeast sexual differentiation. The SAM domain has had various names, including SPM, PTN (pointed), SEP (yeast sterility, Ets-related, PcG proteins), NCR (N-terminal conserved region) and HLH (helix-loop-helix) domain, all of which are related and can be classified as SAM domains.

SAM domains occur in eukaryotic and in some bacterial proteins. Structures have been determined for several proteins that contain SAM domains, including Ets-1 transcription factor, which plays a role in the development and invasion of tumour cells by regulating the expression of matrix-degrading proteases
[3]
; Etv6 transcription factor, gene rearrangements of which have been demonstrated in several malignancies
[4]
; EphA4 receptor tyrosine kinase, which is believed to be important for the correct localization of a motoneuron pool to a specific position in the spinal cord
[5]
; EphB2 receptor, which is involved in spine morphogenesis via intersectin, Cdc42 and N-Wasp
[6]
; p73, a p53 homologue involved in neuronal development
[7]
; and polyhomeotic, which is a member of the Polycomb group of genes (Pc-G) required for the maintenance of the spatial expression pattern of homeotic genes
[8]
.

References
Imported from IPR013761

1.SAM domains: uniform structure, diversity of function. Kim CA, Bowie JU. Trends Biochem. Sci. 28, 625-8, (2003). View articlePMID: 14659692

2.The RNA-binding SAM domain of Smaug defines a new family of post-transcriptional regulators. Aviv T, Lin Z, Lau S, Rendl LM, Sicheri F, Smibert CA. Nat. Struct. Biol. 10, 614-21, (2003). View articlePMID: 12858164

3.The Ets-1 transcription factor is involved in the development and invasion of malignant melanoma. Rothhammer T, Hahne JC, Florin A, Poser I, Soncin F, Wernert N, Bosserhoff AK. Cell. Mol. Life Sci. 61, 118-28, (2004). View articlePMID: 14704859

4.ETV6 gene rearrangements in hematopoietic malignant disorders. Wlodarska I, Mecucci C, Baens M, Marynen P, van den Berghe H. Leuk. Lymphoma 23, 287-95, (1996). PMID: 9031109

5.Role of EphA4 in defining the position of a motoneuron pool within the spinal cord. Coonan JR, Bartlett PF, Galea MP. J. Comp. Neurol. 458, 98-111, (2003). View articlePMID: 12577325

6.EphB receptors regulate dendritic spine development via intersectin, Cdc42 and N-WASP. Irie F, Yamaguchi Y. Nat. Neurosci. 5, 1117-8, (2002). View articlePMID: 12389031

7.Functional regulation of p73 and p63: development and cancer. Melino G, Lu X, Gasco M, Crook T, Knight RA. Trends Biochem. Sci. 28, 663-70, (2003). View articlePMID: 14659698

8.Identification and characterization of polyhomeotic PREs and TREs. Bloyer S, Cavalli G, Brock HW, Dura JM. Dev. Biol. 261, 426-42, (2003). View articlePMID: 14499651

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