SSF50952

Soluble quinoprotein glucose dehydrogenase

SUPERFAMILY entry
Member databaseSUPERFAMILY
SUPERFAMILY typehomologous superfamily

Description
Imported from IPR011041

This superfamily represents the β-propeller domain found in dehydrogenases from all cellular organisms.

Quinoproteins form a class of dehydrogenases distinct from the NAD(P)- and flavin-dependent enzymes, using one of four different quinone cofactors for the oxidation of a variety of compounds. Soluble glucose dehydrogenase (s-GDH) from the bacterium Acinetobacter calcoaceticus is a quinoprotein that requires the cofactor pyrroloquinoline quinone (PQQ) to catalyse the oxidation of glucose to gluconolactone
[1]
. s-GDH has six 4-stranded β-sheets in a β-propeller fold.

References
Imported from IPR011041

1.Active-site structure of the soluble quinoprotein glucose dehydrogenase complexed with methylhydrazine: a covalent cofactor-inhibitor complex. Oubrie A, Rozeboom HJ, Dijkstra BW. Proc. Natl. Acad. Sci. U.S.A. 96, 11787-91, (1999). View articlePMID: 10518528

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