Member database | SUPERFAMILY |
SUPERFAMILY type | homologous superfamily |
Description Imported from IPR011041
This superfamily represents the β-propeller domain found in dehydrogenases from all cellular organisms.
Quinoproteins form a class of dehydrogenases distinct from the NAD(P)- and flavin-dependent enzymes, using one of four different quinone cofactors for the oxidation of a variety of compounds. Soluble glucose dehydrogenase (s-GDH) from the bacterium Acinetobacter calcoaceticus is a quinoprotein that requires the cofactor pyrroloquinoline quinone (PQQ) to catalyse the oxidation of glucose to gluconolactone
[1]. s-GDH has six 4-stranded β-sheets in a β-propeller fold.
References Imported from IPR011041
1.Active-site structure of the soluble quinoprotein glucose dehydrogenase complexed with methylhydrazine: a covalent cofactor-inhibitor complex. Oubrie A, Rozeboom HJ, Dijkstra BW. Proc. Natl. Acad. Sci. U.S.A. 96, 11787-91, (1999). View articlePMID: 10518528