Member database | SUPERFAMILY |
SUPERFAMILY type | homologous superfamily |
Description Imported from IPR036771
This superfamily represents the N-terminal β-sandwich domain of F1F0-ATP synthase subunits delta (in mitochondrial ATPase) and epsilon (in bacteria or chloroplast ATPase)
[2]. The interaction site of subunit C of the F0 complex with the delta or epsilon subunit of the F1 complex may be important for connecting the rotor of F1 (gamma subunit) to the rotor of F0 (C subunit)
[1]. In bacterial species, the delta subunit is the equivalent of the oligomycin sensitive subunit (OSCP,
IPR000711) in metazoans. The C-terminal domain of the epsilon subunit appears to act as an inhibitor of ATPase activity
[3].
References Imported from IPR036771
1.ATP synthases: insights into their motor functions from sequence and structural analyses. Hong S, Pedersen PL. J. Bioenerg. Biomembr. 35, 95-120, (2003). View articlePMID: 12887009
2.Structural and functional analysis of the intrinsic inhibitor subunit epsilon of F1-ATPase from photosynthetic organisms. Yagi H, Konno H, Murakami-Fuse T, Isu A, Oroguchi T, Akutsu H, Ikeguchi M, Hisabori T. Biochem. J. 425, 85-94, (2010). View articlePMID: 19785575
3.Inhibition of ATP hydrolysis by thermoalkaliphilic F1Fo-ATP synthase is controlled by the C terminus of the epsilon subunit. Keis S, Stocker A, Dimroth P, Cook GM. J. Bacteriol. 188, 3796-804, (2006). View articlePMID: 16707672
Integrated to
External Links
Representative structure
2e5y: Epsilon subunit and ATP complex of F1F0-ATP synthase from the Thermophilic Bacillus PS3