Member database | SUPERFAMILY |
SUPERFAMILY type | homologous superfamily |
Description Imported from IPR036434
O-Glycosyl hydrolases (
3.2.1.) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families
[1, 2]. This classification is available on the CAZy (CArbohydrate-Active EnZymes) website.
The 1,4-beta cellobiohydrolase superfamily plays a central role in the recycling of plant biomass. The biological conversion of cellulose to glucose generally requires three types of hydrolytic enzymes: Endoglucanases, which cut internal beta-1,4-glucosidic bonds; exocellobiohydrolases that cut the dissaccharide cellobiose from the non-reducing end of the cellulose polymer chain; and beta-1,4-glucosidases, which hydrolyze the cellobiose and other short cello-oligosaccharides to glucose.
References Imported from IPR036434
1.Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases. Henrissat B, Callebaut I, Fabrega S, Lehn P, Mornon JP, Davies G. Proc. Natl. Acad. Sci. U.S.A. 92, 7090-4, (1995). View articlePMID: 7624375
2.Structures and mechanisms of glycosyl hydrolases. Davies G, Henrissat B. Structure 3, 853-9, (1995). View articlePMID: 8535779
Integrated to
External Links
Representative structure
1bvw: CELLOBIOHYDROLASE II (CEL6A) FROM HUMICOLA INSOLENS