SSF52113

BRCT domain

SUPERFAMILY entry
Member databaseSUPERFAMILY
SUPERFAMILY typehomologous superfamily

Description
Imported from IPR036420

The breast cancer susceptibility gene contains at its C terminus two copies of a conserved domain that was named BRCT for BRCA1 C terminus. This domain of about 95 amino acids is found in a large variety of proteins involved in DNA repair, recombination and cell cycle control
[2, 3, 1]
. The BRCT domain is not limited to the C-terminal of protein sequences and can be found in multiple copies or in a single copy as in RAP1 and TdT. Some data
[4]
indicate that the BRCT domain functions as a protein-protein interaction module.

The structure of the first of the two C-terminal BRCT domains of the human DNA repair protein XRCC1 has been determined by X-ray crystallography, it comprises a four-stranded parallel β-sheet surrounded by three α-helices, which form an autonomously folded domain
[4]
.

References
Imported from IPR036420

1.From BRCA1 to RAP1: a widespread BRCT module closely associated with DNA repair. Callebaut I, Mornon JP. FEBS Lett. 400, 25-30, (1997). View articlePMID: 9000507

2.BRCA1 protein products ... Functional motifs... Koonin EV, Altschul SF, Bork P. Nat. Genet. 13, 266-8, (1996). View articlePMID: 8673121

3.A superfamily of conserved domains in DNA damage-responsive cell cycle checkpoint proteins. Bork P, Hofmann K, Bucher P, Neuwald AF, Altschul SF, Koonin EV. FASEB J. 11, 68-76, (1997). View articlePMID: 9034168

4.Structure of an XRCC1 BRCT domain: a new protein-protein interaction module. Zhang X, Morera S, Bates PA, Whitehead PC, Coffer AI, Hainbucher K, Nash RA, Sternberg MJ, Lindahl T, Freemont PS. EMBO J. 17, 6404-11, (1998). View articlePMID: 9799248

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