SSF54171

DNA-binding domain

SUPERFAMILY entry
Member databaseSUPERFAMILY
SUPERFAMILY typehomologous superfamily

Description
Imported from IPR016177

This superfamily represents a DNA-binding domain with a 2-layer β(3)-α fold that is found in several DNA-binding proteins, including:


 * DNA-binding domain of tn916 integrase
[1]
.
 * N-terminal DNA-binding domain of lambda integrase
[2]
.
 * GCC-box DNA-binding domains of certain transcription factors
[3]
.
 * Methyl-CpG DNA-binding domain found in Methyl-CpG-binding protein 2 (MECP2)
[4]
and methylation-dependent transcriptional repressor MBD1/PCM1
[5]
.

References
Imported from IPR016177

1.Site-specific DNA binding using a variation of the double stranded RNA binding motif. Connolly KM, Wojciak JM, Clubb RT. Nat. Struct. Biol. 5, 546-50, (1998). View articlePMID: 9665166

2.A structural basis for allosteric control of DNA recombination by lambda integrase. Biswas T, Aihara H, Radman-Livaja M, Filman D, Landy A, Ellenberger T. Nature 435, 1059-66, (2005). View articlePMID: 15973401

3.A novel mode of DNA recognition by a beta-sheet revealed by the solution structure of the GCC-box binding domain in complex with DNA. Allen MD, Yamasaki K, Ohme-Takagi M, Tateno M, Suzuki M. EMBO J. 17, 5484-96, (1998). View articlePMID: 9736626

4.The solution structure of the domain from MeCP2 that binds to methylated DNA. Wakefield RI, Smith BO, Nan X, Free A, Soteriou A, Uhrin D, Bird AP, Barlow PN. J. Mol. Biol. 291, 1055-65, (1999). View articlePMID: 10518942

5.Solution structure of the methyl-CpG binding domain of human MBD1 in complex with methylated DNA. Ohki I, Shimotake N, Fujita N, Jee J, Ikegami T, Nakao M, Shirakawa M. Cell 105, 487-97, (2001). View articlePMID: 11371345

Integrated to
External Links
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.