SSF54843

Ribosomal protein L22

SUPERFAMILY entry
Member databaseSUPERFAMILY
SUPERFAMILY typehomologous superfamily

Description
Imported from IPR036394

Large ribosomal subunit protein uL22 (also known as L22 in bacteria and previously known as L17 in eukaryotes) is a core protein of the large ribosomal subunit
[1]
. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper folding and stabilizing the conformation of 23S rRNA. uL22 is the largest protein contributor to the surface of the polypeptide exit channel, the tunnel through which the polypeptide product passes. uL22 is also one of six proteins located at the putative translocon binding site on the exterior surface of the ribosome
[2, 3]
.

References
Imported from IPR036394

1.A new system for naming ribosomal proteins. Ban N, Beckmann R, Cate JH, Dinman JD, Dragon F, Ellis SR, Lafontaine DL, Lindahl L, Liljas A, Lipton JM, McAlear MA, Moore PB, Noller HF, Ortega J, Panse VG, Ramakrishnan V, Spahn CM, Steitz TA, Tchorzewski M, Tollervey D, Warren AJ, Williamson JR, Wilson D, Yonath A, Yusupov M. Curr. Opin. Struct. Biol. 24, 165-9, (2014). View articlePMID: 24524803

2.The complete atomic structure of the large ribosomal subunit at 2.4 A resolution. Ban N, Nissen P, Hansen J, Moore PB, Steitz TA. Science 289, 905-20, (2000). View articlePMID: 10937989

3.L22 ribosomal protein and effect of its mutation on ribosome resistance to erythromycin. Davydova N, Streltsov V, Wilce M, Liljas A, Garber M. J. Mol. Biol. 322, 635-44, (2002). View articlePMID: 12225755

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