SSF55129

Ribosomal protein L30p/L7e

SUPERFAMILY entry
Member databaseSUPERFAMILY
SUPERFAMILY typehomologous superfamily

Description
Imported from IPR036919

Ribosomal protein uL30 is one of the proteins from the large ribosomal subunit. uL30 belongs to a family of ribosomal proteins which, on the basis of sequence similarities
[1]
, groups bacteria and archaea uL30, yeast mitochondrial L33, and Drosophila melanogaster, Dictyostelium discoideum (Slime mold), fungal and mammalian L7 ribosomal proteins which are now referred to as ul30m. uL30 from bacteria are small proteins of about 60 residues, those from archaea are proteins of about 150 residues, and eukaryotic L7 are proteins of about 250 to 270 residues.

This entry represents a domain superfamily with a ferredoxin-like fold, with a core structure consisting of core: β-α-β-α-β. This domain is found in prokaryotic ribosomal protein uL30 (short-chain member of the family), as well as in archaeal uL30 (L30a) (long-chain member of the family), the later containing an additional C-terminal (sub)domain).It is also found in nucleolar proteins with similarity to large ribosomal subunit L7 proteins. These are constituents of 66S pre-ribosomal particles and play an essential role in processing of precursors to the large ribosomal subunit RNAs
[2, 3, 4]
.

References
Imported from IPR036919

1.Yeast ribosomal proteins: XIII. Saccharomyces cerevisiae YL8A gene, interrupted with two introns, encodes a homolog of mammalian L7. Mizuta K, Hashimoto T, Otaka E. Nucleic Acids Res. 20, 1011-6, (1992). View articlePMID: 1549461

2.Two distinct yeast proteins are related to the mammalian ribosomal polypeptide L7. Lalo D, Mariotte S, Thuriaux P. Yeast 9, 1085-91, (1993). View articlePMID: 8256515

3.A nucleolar protein related to ribosomal protein L7 is required for an early step in large ribosomal subunit biogenesis. Dunbar DA, Dragon F, Lee SJ, Baserga SJ. Proc. Natl. Acad. Sci. U.S.A. 97, 13027-32, (2000). View articlePMID: 11087857

4.Role of the yeast Rrp1 protein in the dynamics of pre-ribosome maturation. Horsey EW, Jakovljevic J, Miles TD, Harnpicharnchai P, Woolford JL Jr. RNA 10, 813-27, (2004). View articlePMID: 15100437

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