Member database | SUPERFAMILY |
SUPERFAMILY type | homologous superfamily |
Description Imported from IPR036877
In budding yeast (Saccharomyces cerevisiae), SUI1 is a translation initiation factor that functions in concert with eIF-2 and the initiator tRNA-Met in directing the ribosome to the proper start site of translation
[1]. SUI1 is a protein of 108 residues. Close homologues of SUI1 have been found
[2] in mammals, insects and plants. SUI1 is also evolutionary related to:
* Hypothetical proteins from bacteria such as Escherichia coli (YciH) or Haemophilus influenzae (HI1225).
* Hypothetical proteins from archaea such as Methanococcus jannaschii (MJ0463).
Two eukaryotic proteins also seem to contain a C-terminal SUI1-like domain. These are:
* Density-regulated protein (gene: DENR). This protein is found in mammals, insects, nematodes, plants and fungi.
* Ligatin (gene: LGTN). This protein is found in mammals and insects.
References Imported from IPR036877
1.The suil suppressor locus in Saccharomyces cerevisiae encodes a translation factor that functions during tRNA(iMet) recognition of the start codon. Yoon HJ, Donahue TF. Mol. Cell. Biol. 12, 248-60, (1992). View articlePMID: 1729602
2.Expressed sequence tags identify a human isolog of the suil translation initiation factor. Fields C, Adams MD. Biochem. Biophys. Res. Commun. 198, 288-91, (1994). View articlePMID: 7904817
Integrated to
External Links
Representative structure
5zcy: Crystal structure of archaeal translation initiation factor 1 at 1.5 Angstroms resolution