Member database | SUPERFAMILY |
SUPERFAMILY type | homologous superfamily |
Description Imported from IPR036055
* The ligand-binding domain contains seven or eight 40-amino acid LDLR class A (cysteine-rich) repeats, each of which contains a coordinated calcium ion and six cysteine residues involved in disulphide bond formation
* The second conserved region contains two EGF repeats, followed by six LDLR class B (YWTD) repeats, and another EGF repeat. The LDLR class B repeats each contain a conserved YWTD motif, and is predicted to form a β-propeller structure
* The third domain is rich in serine and threonine residues and contains clustered O-linked carbohydrate chains.
* The fourth domain is the hydrophobic transmembrane region.
* The fifth domain is the cytoplasmic tail that directs the receptor to clathrin-coated pits.
References Imported from IPR036055
1.The human LDL receptor: a cysteine-rich protein with multiple Alu sequences in its mRNA. Yamamoto T, Davis CG, Brown MS, Schneider WJ, Casey ML, Goldstein JL, Russell DW. Cell 39, 27-38, (1984). View articlePMID: 6091915
2.An extracellular beta-propeller module predicted in lipoprotein and scavenger receptors, tyrosine kinases, epidermal growth factor precursor, and extracellular matrix components. Springer TA. J. Mol. Biol. 283, 837-62, (1998). View articlePMID: 9790844
3.Acid-dependent ligand dissociation and recycling of LDL receptor mediated by growth factor homology region. Davis CG, Goldstein JL, Sudhof TC, Anderson RG, Russell DW, Brown MS. Nature 326, 760-5, (1987). View articlePMID: 3494949
4.A receptor-mediated pathway for cholesterol homeostasis. Brown MS, Goldstein JL. Science 232, 34-47, (1986). View articlePMID: 3513311
5.Three-dimensional structure of a cysteine-rich repeat from the low-density lipoprotein receptor. Daly NL, Scanlon MJ, Djordjevic JT, Kroon PA, Smith R. Proc. Natl. Acad. Sci. U.S.A. 92, 6334-8, (1995). View articlePMID: 7603991
6.The LDL receptor-related protein (LRP) family: an old family of proteins with new physiological functions. May P, Woldt E, Matz RL, Boucher P. Ann. Med. 39, 219-28, (2007). View articlePMID: 17457719