SSF88697

PUA domain-like

SUPERFAMILY entry
Member databaseSUPERFAMILY
SUPERFAMILY typehomologous superfamily

Description
Imported from IPR015947

This superfamily represents domains with a PUA-like structure, consisting of a pseudo-barrel composed of mixed folded sheets of five strands. This structural motif is found in:


 * PUA-containing proteins.
 * The N-terminal of ATP sulphurylases, which contains extra structures, some similar to the PK β-barrel domain
[1]
.
 * Several bacterial hypothetical proteins, such as the N-terminal domain of YggJ
[2]
.


The PUA (PseudoUridine synthase and Archaeosine transglycosylase) domain was named after the proteins in which it was first found
[3]
. PUA is a highly conserved RNA-binding motif found in a wide range of archaeal, bacterial and eukaryotic proteins, including enzymes that catalyse tRNA and rRNA post-transcriptional modifications, proteins involved in ribosome biogenesis and translation, as well as in enzymes involved in proline biosynthesis
[4, 5]
. The structures of several PUA-RNA complexes reveal a common RNA recognition surface, but also some versatility in the way in which the motif binds to RNA
[6]
. PUA motifs are involved in dyskeratosis congenita and cancer, pointing to links between RNA metabolism and human diseases
[7]
.

References
Imported from IPR015947

1.Crystal structure of ATP sulfurylase from Saccharomyces cerevisiae, a key enzyme in sulfate activation. Ullrich TC, Blaesse M, Huber R. EMBO J. 20, 316-29, (2001). View articlePMID: 11157739

2.Functional assignment based on structural analysis: crystal structure of the yggJ protein (HI0303) of Haemophilus influenzae reveals an RNA methyltransferase with a deep trefoil knot. Forouhar F, Shen J, Xiao R, Acton TB, Montelione GT, Tong L. Proteins 53, 329-32, (2003). View articlePMID: 14517985

3.Novel predicted RNA-binding domains associated with the translation machinery. Aravind L, Koonin EV. J. Mol. Evol. 48, 291-302, (1999). View articlePMID: 10093218

4.The structure of the RNA m5C methyltransferase YebU from Escherichia coli reveals a C-terminal RNA-recruiting PUA domain. Hallberg BM, Ericsson UB, Johnson KA, Andersen NM, Douthwaite S, Nordlund P, Beuscher AE 4th, Erlandsen H. J. Mol. Biol. 360, 774-87, (2006). View articlePMID: 16793063

5.The RNA-binding PUA domain of archaeal tRNA-guanine transglycosylase is not required for archaeosine formation. Sabina J, Soll D. J. Biol. Chem. 281, 6993-7001, (2006). View articlePMID: 16407303

6.The PUA domain - a structural and functional overview. Perez-Arellano I, Gallego J, Cervera J. FEBS J. 274, 4972-84, (2007). View articlePMID: 17803682

7.Crystal structure of an H/ACA box ribonucleoprotein particle. Li L, Ye K. Nature 443, 302-7, (2006). View articlePMID: 16943774

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