GenProp0038 - Tetrahydrofolate biosynthesis from GTP and PABA
Type: PATHWAYAuthor: Haft DH
Description
Polyglutamylated tetrahydrofolate is the central cofactor of one-carbon metabolism, and is biosynthesized from GTP, para-aminobenzoate (from chorismate), and glutamate in a six step reaction [1]. The first enzyme (GTP cyclohydrolase I) catalizes dihydroneopterin triphosphate from GTP in the biosynthesis of tetrahydrofolate in prokaryotes, of tetrahydrobiopterin in vertebrates, and of pteridine-containing pigments in insects. This pathway is carried out by 6 enzymes, the complete pathway being absent in animals.References
- [1]Transfection studies to explore essential folate metabolism and antifolate drug synergy in the human malaria parasite Plasmodium falciparum. Mol Microbiol. 2004;51:1425-1438. 14982635 EuropePMC
Database Links
Steps
Step | Evidence | Go Terms |
---|---|---|
1. GTP cyclohydrolase I Optional | IPR001474 - TIGR00063 | GO:0046654 |
2. Dihydroneopterin aldolase | IPR006156 - TIGR00525 | GO:0046654 |
3. 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | IPR000550 - TIGR01498 | GO:0046654 |
4. Dihydropteroate synthase | IPR006390 - TIGR01496 | GO:0046654 |
5. Dihydrofolate synthase | IPR001645 - TIGR01499 | GO:0046654 |
6. Dihydrofolate reductase | IPR001796 - | GO:0046654 |