GenProp0038 - Tetrahydrofolate biosynthesis from GTP and PABA

Type: PATHWAY

Author: Haft DH

Description

Polyglutamylated tetrahydrofolate is the central cofactor of one-carbon metabolism, and is biosynthesized from GTP, para-aminobenzoate (from chorismate), and glutamate in a six step reaction [1]. The first enzyme (GTP cyclohydrolase I) catalizes dihydroneopterin triphosphate from GTP in the biosynthesis of tetrahydrofolate in prokaryotes, of tetrahydrobiopterin in vertebrates, and of pteridine-containing pigments in insects. This pathway is carried out by 6 enzymes, the complete pathway being absent in animals.

References

  • [1]Wang P, Wang Q, Aspinall TV, Sims PF, Hyde JE; Transfection studies to explore essential folate metabolism and antifolate drug synergy in the human malaria parasite Plasmodium falciparum. Mol Microbiol. 2004;51:1425-1438. 14982635 EuropePMC

Database Links

  • Folate Biosynthesis (early stages): IUBMB
  • Folate Biosynthesis (late stages): IUBMB
  • Folate Biosynthesis: KEGG

Steps

StepEvidenceGo Terms
1. GTP cyclohydrolase I
Optional
IPR001474 - TIGR00063GO:0046654
2. Dihydroneopterin aldolaseIPR006156 - TIGR00525GO:0046654
3. 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinaseIPR000550 - TIGR01498GO:0046654
4. Dihydropteroate synthaseIPR006390 - TIGR01496GO:0046654
5. Dihydrofolate synthaseIPR001645 - TIGR01499GO:0046654
6. Dihydrofolate reductaseIPR001796 - GO:0046654
Threshold: 2