GenProp0048 - IPP biosynthesis via deoxyxylulose

Type: PATHWAY

Author: Haft DH

Description

Isoprenyl pyrophosphate (IPP) is synthesised in most bacteria by the non-mevalonate pathway (also known as the MEP pathway, the glyceraldehyde-3-phosphate(GAP)-pyruvate pathway and the deoxyxylulose pathway). This is in contrast to the mevalonate pathway found in eukaryotes. This non-mevalonate pathway contains six characterized enzymes and may involve additional proteins as well. IPP is a basic building block of isoprenoids, also known as terpenoids [1].

References

  • [1]Odom AR; Five questions about non-mevalonate isoprenoid biosynthesis. PLoS Pathogens. 2011; 7(12):e1002323. 22216001 EuropePMC

Database Links

  • Non-Mevalonate Terpenoid biosynthesis: IUBMB
  • Sterol biosynthesis: KEGG

Steps

StepEvidenceGo Terms
1. Deoxyxylulose-5-phosphate synthaseIPR005477 - TIGR00204GO:0019288
2. 1-deoxy-D-xylulose 5-phosphate reductoisomeraseIPR003821 - TIGR00243GO:0019288
3. 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferaseIPR001228 - TIGR00453GO:0019288
4. 4-diphosphocytidyl-2C-methyl-D-erythritol kinaseIPR004424 - TIGR00154GO:0019288
5. 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthaseIPR003526 - TIGR00151GO:0019288
6. 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthaseIPR004588 - TIGR00612GO:0019288
7. 4-hydroxy-3-methylbut-2-enyl diphosphate reductaseIPR003451 - TIGR00216GO:0019288
Threshold: 2