GenProp0048 - IPP biosynthesis via deoxyxylulose
Type: PATHWAYAuthor: Haft DH
Description
Isoprenyl pyrophosphate (IPP) is synthesised in most bacteria by the non-mevalonate pathway (also known as the MEP pathway, the glyceraldehyde-3-phosphate(GAP)-pyruvate pathway and the deoxyxylulose pathway). This is in contrast to the mevalonate pathway found in eukaryotes. This non-mevalonate pathway contains six characterized enzymes and may involve additional proteins as well. IPP is a basic building block of isoprenoids, also known as terpenoids [1].References
- [1]Five questions about non-mevalonate isoprenoid biosynthesis. PLoS Pathogens. 2011; 7(12):e1002323. 22216001 EuropePMC
Steps
Step | Evidence | Go Terms |
---|---|---|
1. Deoxyxylulose-5-phosphate synthase | IPR005477 - TIGR00204 | GO:0019288 |
2. 1-deoxy-D-xylulose 5-phosphate reductoisomerase | IPR003821 - TIGR00243 | GO:0019288 |
3. 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase | IPR001228 - TIGR00453 | GO:0019288 |
4. 4-diphosphocytidyl-2C-methyl-D-erythritol kinase | IPR004424 - TIGR00154 | GO:0019288 |
5. 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | IPR003526 - TIGR00151 | GO:0019288 |
6. 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase | IPR004588 - TIGR00612 | GO:0019288 |
7. 4-hydroxy-3-methylbut-2-enyl diphosphate reductase | IPR003451 - TIGR00216 | GO:0019288 |