GenProp0052 - Type III secretion
Type: SYSTEMAuthor: Haft DH
Description
Type III secretion systems are found in a number of pathogenenic gram-negative bacteria. These systems consist of approximately twenty-five translocation proteins, as well as those proteins that are transported either across the bacterial inner and outer membrane, into the medium, or further across a eukaryotic target cell membrane. Substrates for type III secretion are not cleaved during transport, although the signal for transport appears to lie near the N-terminus (or in the RNA); chaperones act as well for some substrates and may be a second signal. Proteins delivered to the target cell cytosol and active in pathogenesis are termed effectors. Type III secretion systems resemble some of the flagellar export apparatus. In some cases, a type III pilus is observed and required for effector delivery. Gene nomeclature transposes across genomes: ysc in Yersinia, bsc in Bordetella, esc in enteropathogenic E. coli, hrc in plant pathogens, etc., so that YscD, EscD, HrcD, etc. are homologous and functionally analogous [1,2,3].References
- [1]Assembly and function of type III secretory systems. Annu Rev Microbiol. 2000;54:735-774. 11018143 EuropePMC
- [2]The Erwinia chrysanthemi type III secretion system is required for multicellular behavior. J Bacteriol. 2005;187:639-648. 15629935 EuropePMC
- [3]Bioinformatics, genomics and evolution of non-flagellar type-III secretion systems: a Darwinian perspective. FEMS Microbiol Rev. 2005;29:201-229. 15808742 EuropePMC
Database Links
- Type III secretion system: KEGG
Steps
Step | Evidence | Go Terms |
---|---|---|
1. HpaP Optional | IPR013390 - TIGR02557 | GO:0030254 |
2. HrpB1/HrpK Optional | IPR013394 - TIGR02561 | GO:0030254 |
3. HrpB2 Optional | IPR013391 - TIGR02558 | GO:0030254 |
4. HrpB4 Optional | IPR013393 - TIGR02560 | GO:0030254 |
5. HrpB7 Optional | IPR013392 - TIGR02559 | GO:0030254 |
6. LcrE/YopN/InvE/MxiC Optional | IPR013401 - TIGR02568 | GO:0030254 |
7. LcrG/PcrG Optional | IPR009863 - TIGR02573 | GO:0030254 |
8. LcrH/SycD/SpaT Optional | IPR005415 - TIGR02552 | GO:0030254 |
9. Regulatory component LcrR Optional | IPR013405 - TIGR02572 | GO:0030254 |
10. OrgA/MxiK Optional | IPR013388 - TIGR02555 | GO:0030254 |
11. PrgH Optional | IPR013387 - TIGR02554 | GO:0030254 |
12. SpaK/InvB/YsaK Optional | IPR003065 - | GO:0030254 |
13. SseC/YopB/EspD Optional | IPR006972 - | GO:0030254 |
14. Type III secretion chaperone SycH Optional | IPR010261 - | GO:0030254 |
15. Type III secretion chaperone SycN Optional | IPR012673 - TIGR02503 | GO:0030254 |
16. Type III secretion effector delivery regulator, TyeA family | IPR013351 - TIGR02511 | GO:0030254 |
17. YopD Optional | IPR008898 - | GO:0030254 |
18. Needle length determinant Optional | IPR013354 - TIGR02514 | GO:0030254 |
19. Type III secretion system needle protein | IPR011841 - TIGR02105 | GO:0030254 |
21. Proximal regulatory components Optional | IPR018060 - | None |
IPR001801 - | None | |
22. Secretin, type III associated Optional | IPR005644 - | GO:0030254 |
24. Secreted proteins, effectors Optional | IPR006972 - | None |
IPR005427 - TIGR02101 | None | |
IPR009483 - TIGR02553 | None | |
25. Type III secretion system chaperone, YscB family Optional | IPR013353 - TIGR02513 | GO:0030254 |
26. Type III secretion outer membrane pore, YscC/HrcC family | IPR003522 - TIGR02516 | GO:0030254 |
27. Type III secretion apparatus protein, YscD/HrpQ family | IPR012843 - TIGR02500 | GO:0030254 |
28. Type III secretion system protein, YseE family Optional | IPR012671 - TIGR02501 | GO:0030254 |
29. Type III secretion protein, YscG family Optional | IPR013348 - TIGR02508 | GO:0030254 |
30. Type III secretion protein YopR(YscH) Optional | IPR013349 - TIGR02509 | GO:0030254 |
31. Type III secretion apparatus protein, YscI/HrpB | IPR012670 - TIGR02497 | GO:0030254 |
32. Type III apparatus lipoprotein, | IPR003282 - TIGR02544 | GO:0030254 |
33. YOP proteins translocation protein K Optional | IPR009510 - | GO:0030254 |
34. Type III secretion apparatus protein, HrpE/YscL family | IPR012842 - TIGR02499 | GO:0030254 |
35. Type III secretion ATPase | IPR013380 - TIGR02546 | GO:0030254 |
36. Type III secretion protein YscO Optional | IPR009929 - | GO:0030254 |
37. YscQ/HrcQ/SpaO | IPR013385 - TIGR02551 | GO:0030254 |
38. Type III secretion apparatus protein, YscR/HrcR family | IPR005773 - TIGR01102 | GO:0030254 |
39. YscS/HrcS/SctS/EscS | IPR006306 - TIGR01403 | GO:0030254 |
40. Type III secretion protein, YscT/HrpX family | IPR006304 - TIGR01401 | GO:0030254 |
41. Type III secretion protein, YscU/HrpY family | IPR006307 - TIGR01404 | GO:0030254 |
42. Type III secretion protein, HrcV | IPR006302 - TIGR01399 | GO:0030254 |
43. Type III secretion chaperone YscW Optional | IPR013400 - TIGR02567 | GO:0030254 |
44. Type III secretion protein, YscX family Optional | IPR012672 - TIGR02502 | GO:0030254 |