GenProp0052 - Type III secretion

Type: SYSTEM

Author: Haft DH

Description

Type III secretion systems are found in a number of pathogenenic gram-negative bacteria. These systems consist of approximately twenty-five translocation proteins, as well as those proteins that are transported either across the bacterial inner and outer membrane, into the medium, or further across a eukaryotic target cell membrane. Substrates for type III secretion are not cleaved during transport, although the signal for transport appears to lie near the N-terminus (or in the RNA); chaperones act as well for some substrates and may be a second signal. Proteins delivered to the target cell cytosol and active in pathogenesis are termed effectors. Type III secretion systems resemble some of the flagellar export apparatus. In some cases, a type III pilus is observed and required for effector delivery. Gene nomeclature transposes across genomes: ysc in Yersinia, bsc in Bordetella, esc in enteropathogenic E. coli, hrc in plant pathogens, etc., so that YscD, EscD, HrcD, etc. are homologous and functionally analogous [1,2,3].

References

  • [1]Cornelis GR, Van Gijsegem F; Assembly and function of type III secretory systems. Annu Rev Microbiol. 2000;54:735-774. 11018143 EuropePMC
  • [2]Yap MN, Yang CH, Barak JD, Jahn CE, Charkowski AO; The Erwinia chrysanthemi type III secretion system is required for multicellular behavior. J Bacteriol. 2005;187:639-648. 15629935 EuropePMC
  • [3]Pallen MJ, Beatson SA, Bailey CM; Bioinformatics, genomics and evolution of non-flagellar type-III secretion systems: a Darwinian perspective. FEMS Microbiol Rev. 2005;29:201-229. 15808742 EuropePMC

Database Links

  • Type III secretion system: KEGG

Steps

StepEvidenceGo Terms
1. HpaP
Optional
IPR013390 - TIGR02557GO:0030254
2. HrpB1/HrpK
Optional
IPR013394 - TIGR02561GO:0030254
3. HrpB2
Optional
IPR013391 - TIGR02558GO:0030254
4. HrpB4
Optional
IPR013393 - TIGR02560GO:0030254
5. HrpB7
Optional
IPR013392 - TIGR02559GO:0030254
6. LcrE/YopN/InvE/MxiC
Optional
IPR013401 - TIGR02568GO:0030254
7. LcrG/PcrG
Optional
IPR009863 - TIGR02573GO:0030254
8. LcrH/SycD/SpaT
Optional
IPR005415 - TIGR02552GO:0030254
9. Regulatory component LcrR
Optional
IPR013405 - TIGR02572GO:0030254
10. OrgA/MxiK
Optional
IPR013388 - TIGR02555GO:0030254
11. PrgH
Optional
IPR013387 - TIGR02554GO:0030254
12. SpaK/InvB/YsaK
Optional
IPR003065 - GO:0030254
13. SseC/YopB/EspD
Optional
IPR006972 - GO:0030254
14. Type III secretion chaperone SycH
Optional
IPR010261 - GO:0030254
15. Type III secretion chaperone SycN
Optional
IPR012673 - TIGR02503GO:0030254
16. Type III secretion effector delivery regulator, TyeA familyIPR013351 - TIGR02511GO:0030254
17. YopD
Optional
IPR008898 - GO:0030254
18. Needle length determinant
Optional
IPR013354 - TIGR02514GO:0030254
19. Type III secretion system needle proteinIPR011841 - TIGR02105GO:0030254
21. Proximal regulatory components
Optional
IPR018060 - None
IPR001801 - None
22. Secretin, type III associated
Optional
IPR005644 - GO:0030254
24. Secreted proteins, effectors
Optional
IPR006972 - None
IPR005427 - TIGR02101None
IPR009483 - TIGR02553None
25. Type III secretion system chaperone, YscB family
Optional
IPR013353 - TIGR02513GO:0030254
26. Type III secretion outer membrane pore, YscC/HrcC familyIPR003522 - TIGR02516GO:0030254
27. Type III secretion apparatus protein, YscD/HrpQ familyIPR012843 - TIGR02500GO:0030254
28. Type III secretion system protein, YseE family
Optional
IPR012671 - TIGR02501GO:0030254
29. Type III secretion protein, YscG family
Optional
IPR013348 - TIGR02508GO:0030254
30. Type III secretion protein YopR(YscH)
Optional
IPR013349 - TIGR02509GO:0030254
31. Type III secretion apparatus protein, YscI/HrpBIPR012670 - TIGR02497GO:0030254
32. Type III apparatus lipoprotein,IPR003282 - TIGR02544GO:0030254
33. YOP proteins translocation protein K
Optional
IPR009510 - GO:0030254
34. Type III secretion apparatus protein, HrpE/YscL familyIPR012842 - TIGR02499GO:0030254
35. Type III secretion ATPaseIPR013380 - TIGR02546GO:0030254
36. Type III secretion protein YscO
Optional
IPR009929 - GO:0030254
37. YscQ/HrcQ/SpaOIPR013385 - TIGR02551GO:0030254
38. Type III secretion apparatus protein, YscR/HrcR familyIPR005773 - TIGR01102GO:0030254
39. YscS/HrcS/SctS/EscSIPR006306 - TIGR01403GO:0030254
40. Type III secretion protein, YscT/HrpX familyIPR006304 - TIGR01401GO:0030254
41. Type III secretion protein, YscU/HrpY familyIPR006307 - TIGR01404GO:0030254
42. Type III secretion protein, HrcVIPR006302 - TIGR01399GO:0030254
43. Type III secretion chaperone YscW
Optional
IPR013400 - TIGR02567GO:0030254
44. Type III secretion protein, YscX family
Optional
IPR012672 - TIGR02502GO:0030254
Threshold: 0