GenProp0061 - Lipoprotein system lgt/lsp/lnt

Type: SYSTEM

Author: Haft DH

Description

Some membrane proteins are anchored to the membrane by a lipid moiety attached to a modified N-terminus rather than by a transmembrane helix. This property describes such a system. The system starts with the modification of the Cys sulfhydryl of the conserved lipobox motif L-X-G/A-C by prolipoprotein diacylglyceryl transferase (Lgt). Prolipoprotein signal peptidase (Lsp) then cleaves the lipoprotein signal sequence leaving Cys as the new N-terminal residue. Finally the Cys NH2 is acylated by apolipoprotein N-acyltransferase (Lnt) [1].

References

  • [1]Sankaran K, Wu HC; Lipid modification of bacterial prolipoprotein. Transfer of diacylglyceryl moiety from phosphatidylglycerol. J Biol Chem. 1994;269(31):19701-6. 8051048 EuropePMC

Database Links

    None

Steps

StepEvidenceGo Terms
1. Prolipoprotein diacylglyceryl transferaseIPR001640 - TIGR00544GO:0042158
2. Prolipoprotein signal peptidaseIPR001872 - TIGR00077GO:0042158
3. Apolipoprotein N-acyltransferase
Optional
IPR004563 - TIGR00546GO:0042158
Threshold: 0