GenProp0061 - Lipoprotein system lgt/lsp/lnt
Type: SYSTEMAuthor: Haft DH
Description
Some membrane proteins are anchored to the membrane by a lipid moiety attached to a modified N-terminus rather than by a transmembrane helix. This property describes such a system. The system starts with the modification of the Cys sulfhydryl of the conserved lipobox motif L-X-G/A-C by prolipoprotein diacylglyceryl transferase (Lgt). Prolipoprotein signal peptidase (Lsp) then cleaves the lipoprotein signal sequence leaving Cys as the new N-terminal residue. Finally the Cys NH2 is acylated by apolipoprotein N-acyltransferase (Lnt) [1].References
- [1]Lipid modification of bacterial prolipoprotein. Transfer of diacylglyceryl moiety from phosphatidylglycerol. J Biol Chem. 1994;269(31):19701-6. 8051048 EuropePMC
Database Links
- None
Steps
Step | Evidence | Go Terms |
---|---|---|
1. Prolipoprotein diacylglyceryl transferase | IPR001640 - TIGR00544 | GO:0042158 |
2. Prolipoprotein signal peptidase | IPR001872 - TIGR00077 | GO:0042158 |
3. Apolipoprotein N-acyltransferase Optional | IPR004563 - TIGR00546 | GO:0042158 |