GenProp0139 - Degradation of tyrosine via homogentisate
Type: PATHWAYAuthor: Haft DH, Richardson L.
Description
Tyrosine is degraded to produce fumarate and acetoacetate via the intermediate homogentisate, in a five-step pathway. Tyrosine is converted to 4-hydroxyphenylpyruvate by TyrB (tyrosine transaminase also known as tyrosine aminotransferase or PhhC) and then to homogentisate by Hpd (4-hydroxyphenylpyruvate dioxygenase). The second part of the pathway (the catabolism of homogentisate) involves three enzymes: HmgA (homogentisate dioxygenase); HmgB (fumarylacetoacetate hydrolase, also known as Fah); and HmgC (maleylacetoacetate isomerase, also known as Mai) [1].References
- [1]The homogentisate pathway: a central catabolic pathway involved in the degradation of L-phenylalanine, L-tyrosine, and 3-hydroxyphenylacetate in Pseudomonas putida. J Bacteriol. 2004;186(15):5062-5077. 15262943 EuropePMC
Database Links
- Tyrosine metabolism: KEGG
Steps
Step | Evidence | Go Terms |
---|---|---|
1. Tyrosine transaminase Optional | IPR005957 - TIGR01264 | GO:0019445 |
2. 4-hydroxyphenylpyruvate dioxygenase | IPR005956 - TIGR01263 | GO:0019445 |
3. Homogentisate 1,2-dioxygenase | IPR005708 - TIGR01015 | GO:0019445 |
IPR005708 - | GO:0019445 | |
4. Maleylacetoacetate isomerase | IPR005955 - TIGR01262 | GO:0019445 |
5. Fumarylacetoacetase | IPR005959 - TIGR01266 | GO:0019445 |
IPR011234 - | GO:0019445 |