GenProp0139 - Degradation of tyrosine via homogentisate

Type: PATHWAY

Author: Haft DH, Richardson L.

Description

Tyrosine is degraded to produce fumarate and acetoacetate via the intermediate homogentisate, in a five-step pathway. Tyrosine is converted to 4-hydroxyphenylpyruvate by TyrB (tyrosine transaminase also known as tyrosine aminotransferase or PhhC) and then to homogentisate by Hpd (4-hydroxyphenylpyruvate dioxygenase). The second part of the pathway (the catabolism of homogentisate) involves three enzymes: HmgA (homogentisate dioxygenase); HmgB (fumarylacetoacetate hydrolase, also known as Fah); and HmgC (maleylacetoacetate isomerase, also known as Mai) [1].

References

  • [1]Arias-Barrau E, Olivera ER, Luengo JM, Fernández C, Galán B, García JL, Díaz E, Miñambres B; The homogentisate pathway: a central catabolic pathway involved in the degradation of L-phenylalanine, L-tyrosine, and 3-hydroxyphenylacetate in Pseudomonas putida. J Bacteriol. 2004;186(15):5062-5077. 15262943 EuropePMC

Database Links

  • Tyrosine metabolism: KEGG

Steps

StepEvidenceGo Terms
1. Tyrosine transaminase
Optional
IPR005957 - TIGR01264GO:0019445
2. 4-hydroxyphenylpyruvate dioxygenaseIPR005956 - TIGR01263GO:0019445
3. Homogentisate 1,2-dioxygenaseIPR005708 - TIGR01015GO:0019445
IPR005708 - GO:0019445
4. Maleylacetoacetate isomeraseIPR005955 - TIGR01262GO:0019445
5. FumarylacetoacetaseIPR005959 - TIGR01266GO:0019445
IPR011234 - GO:0019445
Threshold: 0