GenProp0171 - TCA cycle
Type: METAPATHAuthor: Haft DH
Description
The TCA cycle (also known as the Krebs cycle, citrate acid cycle, and tricarboxylic acid cycle) is performed in eukaryotic mitochondria and in many prokaryotes. This property refers to the forward direction: from oxaloacetate and acetate to citrate, to isocitrate, to 2-oxoglutarate, to succinate, to fumarate, to malate, to oxaloacetate, with the release of two molecules of CO2. It runs only under aerobic conditions. The state YES means the cycle is complete. A complete TCA cycle may correlate with use of TCA intermediates as biosynthetic precursors and with anaplerotic (TCA cycle intermediate-replenishing) reactions such as the glyoxylate shunt. The state PARTIAL indicates the pathway does not form a full cycle but may contain several consecutive steps. The direction of flux through this arc is not specified when the PARTIAL state is set, and so it may be in the reductive (reverse) direction. The full reverse TCA cycle, an alternative to the Calvin cycle for carbon dioxide fixation, is covered by a separate property.References
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