GenProp0478 - Acetyl-CoA -- acetate interconversion via acetyl phosphate
Type: PATHWAYAuthor: Haft DH
Description
Acetate and acetyl-CoA can be interconverted by any of several routes. This pathway utilizes acetyl phosphate as an intermediate. This system is used in E. coli and other bacteria for the utilization of acetate as a carbon source [1]. Alternatively, the reactions may be run in the catabolic direction in fermentations in order to produce ATP and excrete acetate.References
- [1]Enzymatic phosphorylation of acetate. J Biol Chem. 1954;211:737-756. 13221579 EuropePMC
- [2]Regulation of acetyl coenzyme A synthetase in Escherichia coli. J Bacteriol. 2000;182:4173-4179. 10894724 EuropePMC
- [3]Purification and characterization of two extremely thermostable enzymes, phosphate acetyltransferase and acetate kinase, from the hyperthermophilic eubacterium Thermotoga maritima. J Bacteriol. 1999;181:1861-1867. 10074080 EuropePMC
Database Links
- None
Steps
Step | Evidence | Go Terms |
---|---|---|
1. Phosphate acetyltransferase | IPR004614 - TIGR00651 | GO:0019427 |
2. Acetyl kinase | IPR004372 - TIGR00016 | GO:0019427 |