GenProp0478 - Acetyl-CoA -- acetate interconversion via acetyl phosphate

Type: PATHWAY

Author: Haft DH

Description

Acetate and acetyl-CoA can be interconverted by any of several routes. This pathway utilizes acetyl phosphate as an intermediate. This system is used in E. coli and other bacteria for the utilization of acetate as a carbon source [1]. Alternatively, the reactions may be run in the catabolic direction in fermentations in order to produce ATP and excrete acetate.

References

  • [1]ROSE IA, GRUNBERG-MANAGO M, KOREY SR, OCHOA S; Enzymatic phosphorylation of acetate. J Biol Chem. 1954;211:737-756. 13221579 EuropePMC
  • [2]Kumari S, Beatty CM, Browning DF, Busby SJ, Simel EJ, Hovel-Miner G, Wolfe AJ; Regulation of acetyl coenzyme A synthetase in Escherichia coli. J Bacteriol. 2000;182:4173-4179. 10894724 EuropePMC
  • [3]Bock AK, Glasemacher J, Schmidt R, Schönheit P; Purification and characterization of two extremely thermostable enzymes, phosphate acetyltransferase and acetate kinase, from the hyperthermophilic eubacterium Thermotoga maritima. J Bacteriol. 1999;181:1861-1867. 10074080 EuropePMC

Database Links

    None

Steps

StepEvidenceGo Terms
1. Phosphate acetyltransferaseIPR004614 - TIGR00651GO:0019427
2. Acetyl kinaseIPR004372 - TIGR00016GO:0019427
Threshold: 1