A0A085A595

Methionine synthase

UniProtKB/TrEMBL protein
Short nameA0A085A595_9ENTR
Length1227 amino acids
SpeciesTrabulsiella guamensis ATCC 49490
GenemetH
Function
Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate
Family membership
Entry matches to this protein
Feature Display Mode
Summary
Full
112271002003004005006007008009001,0001,1001,200
5001000
B12_…B12_BINDI…ADOMET_ACTIVATIONPTERIN_BINDINGHCY
Representative domains
MeTr
Substrate binding pocket
methionine_syntha…
Cobalt ligand
B12 binding site
MetH
BINDING: S-adenosyl-L-methionine.
BINDING: Methylcob(III)alamin.
BINDING: Methylcob(III)alamin; via amide nitrogen.
REGION: S-adenosyl-L-methionine binding.
BINDING: S-adenosyl-L-methionine; via carbonyl oxygen.
REGION: Methylcob(III)alamin binding.
BINDING: Zn(2+).
BINDING: methylcob(III)alamin / Co; axial binding residue.
PIRSR
METAL: Zinc.

InterPro GO terms

Panther GO terms
PTHR45833:SF1
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