A0A1A2P466

Inosine-5'-monophosphate dehydrogenase

UniProtKB/TrEMBL protein
Short nameA0A1A2P466_9MYCO
Length536 amino acids
SpeciesMycobacterium sp. E1319
GeneguaB
Function
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growt...
Family membership
Entry matches to this protein
Feature Display Mode
Summary
Full
153650100150200250300350400450500
200400
IMPDH
Active site
CBS_pair_IMPDH
Ligand binding site I
Ligand binding site II
IMPDH
ACT_SITE: Proton acceptor.
ACT_SITE: Thioimidate intermediate.
NP_BIND: NAD.
METAL: Potassium; via carbonyl oxygen.
BINDING: IMP.
REGION: IMP binding.
PIRSR
ACT_SITE: Thioimidate intermediate.
METAL: Potassium; via carbonyl oxygen.

InterPro GO terms

Panther GO terms
PTHR11911:SF111
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