A0A1L8U1J3

Inosine-5'-monophosphate dehydrogenase

UniProtKB/TrEMBL protein
Short nameA0A1L8U1J3_ENTGA
Length494 amino acids
SpeciesEnterococcus gallinarum
ProteomeUP000254807
GeneguaB
Function
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growt...
Family membership
Entry matches to this protein
Feature Display Mode
Summary
Full
149450100150200250300350400450
200400
IMPDH
Active site
CBS_pair_IMPDH
Ligand binding site II
Ligand binding site I
IMPDH
REGION: IMP binding.
BINDING: IMP.
ACT_SITE: Proton acceptor.
ACT_SITE: Thioimidate intermediate.
NP_BIND: NAD.
METAL: Potassium; via carbonyl oxygen.
PIRSR
ACT_SITE: Thioimidate intermediate.
METAL: Potassium; via carbonyl oxygen.

InterPro GO terms

Panther GO terms
PTHR11911:SF111
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