A0A3N6PZJ2

Inosine-5'-monophosphate dehydrogenase

UniProtKB/TrEMBL protein
Short nameA0A3N6PZJ2_9BURK
Length486 amino acids
SpeciesParaburkholderia dinghuensis
ProteomeUP000272778
GeneguaB
Function
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growt...
Family membership
Entry matches to this protein
148650100150200250300350400450
200400
IMPDH
Active site
CBS_pair_IMPDH
Ligand binding site I
Ligand binding site II
IMPDH
METAL: Potassium; via carbonyl oxygen.
BINDING: IMP.
REGION: IMP binding.
ACT_SITE: Thioimidate intermediate.
ACT_SITE: Proton acceptor.
NP_BIND: NAD.
PIRSR
NP_BIND: FMN.
BINDING: Glyoxylate.
ACT_SITE: Thioimidate intermediate.
METAL: Potassium; via carbonyl oxygen.

InterPro GO terms

Panther GO terms
PTHR11911:SF111
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