A0A8I3WB02

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma

UniProtKB/TrEMBL protein
Short nameA0A8I3WB02_CALJA
Length1315 amino acids
SpeciesCallithrix jacchus (White-tufted-ear marmoset)
ProteomeUP000008225
GenePLCG1
Function
Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades
Family membership
Entry matches to this protein
Feature Display Mode
Summary
Full
113151002003004005006007008009001,0001,1001,2001,300
5001000
PHPIPLC_Y…S…EFh_PI-PLC…PH_PLC…PH…SH2_…PI-PLCc_ga…C2_PLC_…
Representative domains
C2_PLC_…
Ca2+ binding pocket
PI-PLCc_ga…
Putative Ca binding site
Catalytic site
SH2_…
Phosphotyrosine binding pocket
Hydrophobic binding pocket
SH2_…
Hydrophobic binding pocket
Phosphotyrosine binding pocket
S…
Peptide ligand binding site
PH…
Rac2 binding site
PH_PLC…
Putative Rac1 binding site
Putative phosphoinositide binding site
PLC-gamma
MOD_RES: Phosphoserine.
PIRSR
BINDING: Ca(2+)
ACT_SITE:
BINDING: Ca(2+)
BINDING: Substrate.
METAL: Calcium 1; catalytic.
METAL: Calcium 2; via carbonyl oxygen.
METAL: Calcium 3.

InterPro GO terms

Panther GO terms
PTHR10336:SF173
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