A0A949V470

Inosine-5'-monophosphate dehydrogenase

UniProtKB/TrEMBL protein
Short nameA0A949V470_CHLSQ
Length497 amino acids
SpeciesChlorobium sp.
GeneguaB
Function
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growt...
Family membership
Entry matches to this protein
Feature Display Mode
Summary
Full
149750100150200250300350400450
200400
IMPDH
Active site
CBS_pair_IMPDH
Ligand binding site I
Ligand binding site II
IMPDH
NP_BIND: NAD.
METAL: Potassium; via carbonyl oxygen.
REGION: IMP binding.
BINDING: IMP.
ACT_SITE: Proton acceptor.
ACT_SITE: Thioimidate intermediate.
PIRSR
ACT_SITE: Thioimidate intermediate.
METAL: Potassium; via carbonyl oxygen.
ACT_SITE: Proton donor.
METAL: Divalent metal cation.
BINDING: Substrate; via amide nitrogen.
REGION: Substrate binding.

InterPro GO terms

Panther GO terms
PTHR11911:SF111
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