G1DFN8

DNA repair nuclease/redox regulator APEX1

UniProtKB/TrEMBL protein
Short nameG1DFN8_CAPHI
Length318 amino acids
SpeciesCapra hircus (Goat)
GeneAPEX1
Function
Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends
Family membership
Entry matches to this protein
Feature Display Mode
Summary
Full
131850100150200250300
100200300
Ape1-like_AP-endo
DNA binding site
Metal binding site A
Putative phosphate binding site
Metal binding site B
Active site
AP binding site
Putative catalytic site
PIRSR
ACT_SITE: Proton donor/acceptor
ACT_SITE:
ACT_SITE: Proton acceptor
BINDING: Mg(2+)
SITE: Interaction with DNA substrate
SITE: Important for catalytic activity
SITE: Transition state stabilizer

InterPro GO terms

Panther GO terms
PTHR22748:SF6
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