H8XX85
Genome polyprotein
UniProtKB/TrEMBL protein
Short name | H8XX85_9FLAV |
Length | 3387 amino acids |
Species | dengue virus type 4 |
Function | Component of the viral RNA replication complex that functions in virion assembly and antagonizes the host immune response |
Family membership |
Entry matches to this protein
Representative families
Representative domains
Homodimer interface
Low pH domain interface
Low pH trimer interface
Glycoprotein E binding interface
ATP binding site
Putative ATP binding site
Homodimer interface
SAM binding site
Nucleic acid substrate binding site
Active site
ACT_SITE: Charge relay system; for serine protease NS3 activity.
DISULFID:
BINDING: S-adenosyl-L-methionine.
BINDING: S-adenosyl-L-methionine; via carbonyl oxygen.
METAL: Zinc 1.
METAL: Zinc 2.
METAL: Zinc 2; via tele nitrogen.
METAL: Zinc 1; via tele nitrogen.
phobius: NON_CYTOPLASMIC_DOMAIN
phobius: TRANSMEMBRANE
phobius: CYTOPLASMIC_DOMAIN
tmhmm: TMhelix
InterPro GO terms
biological process
molecular function
- protein dimerization activity (GO:0046983)
- serine-type endopeptidase activity (GO:0004252)
- RNA binding (GO:0003723)
- RNA helicase activity (GO:0003724)
- ATP binding (GO:0005524)
- helicase activity (GO:0004386)
- mRNA 5'-cap (guanine-N7-)-methyltransferase activity (GO:0004482)
- mRNA (nucleoside-2'-O-)-methyltransferase activity (GO:0004483)
- RNA-dependent RNA polymerase activity (GO:0003968)
- hydrolase activity, acting on acid anhydrides (GO:0016817)
- ribonucleoside triphosphate phosphatase activity (GO:0017111)
- structural molecule activity (GO:0005198)
- double-stranded RNA binding (GO:0003725)
- methyltransferase activity (GO:0008168)
cellular component