P34914
Bifunctional epoxide hydrolase 2
UniProtKB/Swiss-Prot protein
Short name | HYES_MOUSE |
Length | 554 amino acids |
Species | Mus musculus (Mouse) |
Proteome | UP000000589 |
Gene | Ephx2 |
Function | Bifunctional enzyme. The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides (PubMed:21217101, PubMed:7840649). Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides... |
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Isoforms |
Entry matches to this protein
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Summary
Full
Representative families
Representative domains
Active site
Homodimer interface
Mg2+ ligand
Stabilizes negatively charged intermediate
Mg2+ ligand, binds phosphate moiety of substrate
Binds phosphate moiety of substrate
Nucleophile: attacks phosphate moiety of substrate to form covalent intermediate
Mg2+ ligand, nucleophile: attacks phosphate moiety of intermediate to form covalent intermediate
PIRSR
ACT_SITE: Proton donor.
ACT_SITE: Nucleophile.
BINDING: Substrate.
REGION: Substrate binding.
METAL: Magnesium 1.
METAL: Magnesium 2; via carbonyl oxygen.
METAL: Magnesium 2.
SITE: Important for catalytic activity and assists the phosphoryl transfer reaction to Asp8 by balancing charge and orienting the reacting groups.