P34914

Bifunctional epoxide hydrolase 2

UniProtKB/Swiss-Prot protein
Short nameHYES_MOUSE
Length554 amino acids
SpeciesMus musculus (Mouse)
ProteomeUP000000589
GeneEphx2
Function
Bifunctional enzyme. The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides (PubMed:21217101, PubMed:7840649). Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides...
Family membership
Isoforms
Entry matches to this protein
Feature Display Mode
Summary
Full
155450100150200250300350400450500550
200400
HAD_sEH-N_like
Active site
Homodimer interface
epoxide_hydrolase_n-terminal_p
Mg2+ ligand
Stabilizes negatively charged intermediate
Mg2+ ligand, binds phosphate moiety of substrate
Binds phosphate moiety of substrate
Nucleophile: attacks phosphate moiety of substrate to form covalent intermediate
C1.5:_HAD__Beta-PGM__Phosphata
Mg2+ ligand, nucleophile: attacks phosphate moiety of intermediate to form covalent intermediate
PIRSR
ACT_SITE: Proton donor.
ACT_SITE: Nucleophile.
BINDING: Substrate.
REGION: Substrate binding.
METAL: Magnesium 1.
METAL: Magnesium 2; via carbonyl oxygen.
METAL: Magnesium 2.
SITE: Important for catalytic activity and assists the phosphoryl transfer reaction to Asp8 by balancing charge and orienting the reacting groups.

InterPro GO terms

biological process

  • None

cellular component

  • None
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