Q1PUU5

Inosine-5'-monophosphate dehydrogenase

UniProtKB/TrEMBL protein
Short nameQ1PUU5_KUEST
Length511 amino acids
SpeciesKuenenia stuttgartiensis
GeneguaB
Function
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growt...
Family membership
Entry matches to this protein
151150100150200250300350400450500
200400
IMPDH
Active site
CBS_pair_IMPDH
Ligand binding site II
Ligand binding site I
IMPDH
ACT_SITE: Proton acceptor.
ACT_SITE: Thioimidate intermediate.
NP_BIND: NAD.
METAL: Potassium; via carbonyl oxygen.
PIRSR
ACT_SITE: Thioimidate intermediate.
METAL: Potassium; via carbonyl oxygen.

InterPro GO terms

Panther GO terms
PTHR11911:SF111
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