Q62406
Interleukin-1 receptor-associated kinase 1
UniProtKB/Swiss-Prot protein
Short name | IRAK1_MOUSE |
Length | 710 amino acids |
Species | Mus musculus (Mouse) |
Proteome | UP000000589 |
Gene | Irak1 |
Function | Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling comp... |
Family membership | None predicted |
Isoforms |
Entry matches to this protein
Representative domains
Putative IRAK1-IRAK4 interaction site
PIRSR
BINDING: ATP.
BINDING: ATP
METAL: Magnesium; via carbonyl oxygen.
ACT_SITE: Proton acceptor.
NP_BIND: ATP.
BINDING: ATP.
METAL: Magnesium.
CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
InterPro GO terms
biological process
molecular function
cellular component
- None
Panther GO terms
PTHR27001:SF939
biological process
molecular function
- None
cellular component