Q62406

Interleukin-1 receptor-associated kinase 1

UniProtKB/Swiss-Prot protein
Short nameIRAK1_MOUSE
Length710 amino acids
SpeciesMus musculus (Mouse)
ProteomeUP000000589
GeneIrak1
Function
Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling comp...
Family membership
None predicted
Isoforms
Entry matches to this protein
1710100200300400500600700
200400600
Representative families
Death_IRAK1
Putative IRAK1-IRAK4 interaction site
PIRSR
BINDING: ATP.
BINDING: ATP
METAL: Magnesium; via carbonyl oxygen.
ACT_SITE: Proton acceptor.
NP_BIND: ATP.
BINDING: ATP.
METAL: Magnesium.
CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)

InterPro GO terms

Panther GO terms
PTHR27001:SF939

molecular function

  • None
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.