Q8CFH6
Serine/threonine-protein kinase SIK2
UniProtKB/Swiss-Prot protein
Short name | SIK2_MOUSE |
Length | 931 amino acids |
Species | Mus musculus (Mouse) |
Proteome | UP000000589 |
Gene | Sik2 |
Function | Serine/threonine-protein kinase that plays a role in many biological processes such as fatty acid oxidation, autophagy, immune response or glucose metabolism (PubMed:12624099, PubMed:16817901, PubMed:29211348). Phosphorylates 'Ser-794' of IRS1 in ins... |
Family membership |
Entry matches to this protein
Representative families
Representative domains
Polypeptide substrate binding site
ATP binding site
Active site
Activation loop (A-loop)
BINDING: ATP.
NP_BIND: ATP.
ACT_SITE: Proton acceptor.
PIRSR
METAL: Magnesium; via carbonyl oxygen.
BINDING: ATP; via carbonyl oxygen.
ACT_SITE: Proton acceptor.
BINDING: ATP.
NP_BIND: ATP.
METAL: Magnesium.
CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
InterPro GO terms
biological process
molecular function
cellular component
- None
Panther GO terms
PTHR24346:SF38
biological process
molecular function
cellular component