Q8CFH6

Serine/threonine-protein kinase SIK2

UniProtKB/Swiss-Prot protein
Short nameSIK2_MOUSE
Length931 amino acids
SpeciesMus musculus (Mouse)
ProteomeUP000000589
GeneSik2
Function
Serine/threonine-protein kinase that plays a role in many biological processes such as fatty acid oxidation, autophagy, immune response or glucose metabolism (PubMed:12624099, PubMed:16817901, PubMed:29211348). Phosphorylates 'Ser-794' of IRS1 in ins...
Family membership
Entry matches to this protein
1931100200300400500600700800900
200400600800
MobiDB-lite: Consensus Disorder Prediction
Polar
Low complexity
Proline-rich
STKc_SIK
Polypeptide substrate binding site
ATP binding site
Active site
Activation loop (A-loop)
Ser/Thr_PK_SNF1-like
BINDING: ATP.
NP_BIND: ATP.
ACT_SITE: Proton acceptor.
PIRSR
METAL: Magnesium; via carbonyl oxygen.
BINDING: ATP; via carbonyl oxygen.
ACT_SITE: Proton acceptor.
BINDING: ATP.
NP_BIND: ATP.
METAL: Magnesium.
CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)

InterPro GO terms

Panther GO terms
PTHR24346:SF38
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