A0A023R914
Genome polyprotein
UniProtKB/TrEMBL protein
Short name | A0A023R914_HE71 |
Length | 2193 amino acids |
Species | Human enterovirus 71 (EV71) |
Gene | CN12_49020gpPOL |
Function | Acts as a primer for viral RNA replication and remains covalently bound to viral genomic RNA. VPg is uridylylated prior to priming replication into VPg-pUpU. The oriI viral genomic sequence may act as a template for this. The VPg-pUpU is then used as... |
Family membership |
Entry matches to this protein
Feature Display Mode
Summary
Full
Representative families
Representative domains
Drug-binding pocket
Conserved polymerase motif B
NTP binding site
Conserved polymerase motif A
RNA binding site
Conserved polymerase motif F
Conserved polymerase motif C
PIRSR
ACT_SITE: For RdRp activity.
NP_BIND: ATP.
SITE: Cleavage; by protease 3C.
coils: Coil
phobius: NON_CYTOPLASMIC_DOMAIN
phobius: TRANSMEMBRANE
phobius: CYTOPLASMIC_DOMAIN
InterPro GO terms
biological process
molecular function
- structural molecule activity (GO:0005198)
- peptidase activity (GO:0008233)
- ATP hydrolysis activity (GO:0016887)
- RNA binding (GO:0003723)
- RNA helicase activity (GO:0003724)
- RNA-dependent RNA polymerase activity (GO:0003968)
- cysteine-type endopeptidase activity (GO:0004197)
- ribonucleoside triphosphate phosphatase activity (GO:0017111)
cellular component