O14727

Apoptotic protease-activating factor 1

UniProtKB/Swiss-Prot protein
Short nameAPAF_HUMAN
Length1248 amino acids
SpeciesHomo sapiens (Human)
ProteomeUP000005640
GeneAPAF1
Function
Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis
Family membership
Isoforms
Entry matches to this protein
Feature Display Mode
Summary
Full
112481002003004005006007008009001,0001,1001,200
5001000
CARDAP…APAF1_CNB-ARCWD40WD40
Representative domains
WD40WD40
Structural tetrad
CAR…
APAF1-Caspase9 interaction site
Apop_pept_activating-1
BINDING: ATP.
NP_BIND: ATP.

InterPro GO terms

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.