O14727
Apoptotic protease-activating factor 1
UniProtKB/Swiss-Prot protein
Short name | APAF_HUMAN |
Length | 1248 amino acids |
Species | Homo sapiens (Human) |
Proteome | UP000005640 |
Gene | APAF1 |
Function | Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis |
Family membership | |
Isoforms |
Entry matches to this protein
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biological process
molecular function
cellular component