P03956

Interstitial collagenase

UniProtKB/Swiss-Prot protein
Short nameMMP1_HUMAN
Length469 amino acids
SpeciesHomo sapiens (Human)
ProteomeUP000005640
GeneMMP1
Function
Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X (PubMed:1645757, PubMed:2153297, PubMed:2557822). In case of HIV infection, interacts and cleaves the secreted viral Tat protein, l...
Family membership
Entry matches to this protein
Feature Display Mode
Summary
Full
146950100150200250300350400450
200400
HX
Metal binding sites
ZnMc_MMP
Active site
TIMP-binding surface
Peptidase_M10A_matrix
ACT_SITE:
PIRSR
METAL: Zinc; via tele nitrogen; catalytic.
METAL: Zinc; catalytic.
ACT_SITE:
METAL: Calcium 2.
METAL: Calcium 2; via carbonyl oxygen.
METAL: Zinc 2; via carbonyl oxygen; catalytic.
METAL: Calcium 3; via carbonyl oxygen.
METAL: Zinc 1.
METAL: Calcium 1; via carbonyl oxygen.
METAL: Calcium 5; via carbonyl oxygen.
METAL: Calcium 1.
METAL: Calcium 3.
METAL: Zinc 2; via tele nitrogen; catalytic.
METAL: Zinc 1; via pros nitrogen.
METAL: Calcium 4; via carbonyl oxygen.
METAL: Zinc 1; via tele nitrogen.
METAL: Zinc 2; in inhibited form.
MOD_RES: Phosphotyrosine; by PKDCC.
MOTIF: Cysteine switch.

InterPro GO terms

Panther GO terms
PTHR10201:SF151
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