P03956
Interstitial collagenase
UniProtKB/Swiss-Prot protein
Short name | MMP1_HUMAN |
Length | 469 amino acids |
Species | Homo sapiens (Human) |
Proteome | UP000005640 |
Gene | MMP1 |
Function | Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X (PubMed:1645757, PubMed:2153297, PubMed:2557822). In case of HIV infection, interacts and cleaves the secreted viral Tat protein, l... |
Family membership |
Entry matches to this protein
Feature Display Mode
Summary
Full
Representative families
Representative domains
Metal binding sites
Active site
TIMP-binding surface
ACT_SITE:
PIRSR
METAL: Zinc; via tele nitrogen; catalytic.
METAL: Zinc; catalytic.
ACT_SITE:
METAL: Calcium 2.
METAL: Calcium 2; via carbonyl oxygen.
METAL: Zinc 2; via carbonyl oxygen; catalytic.
METAL: Calcium 3; via carbonyl oxygen.
METAL: Zinc 1.
METAL: Calcium 1; via carbonyl oxygen.
METAL: Calcium 5; via carbonyl oxygen.
METAL: Calcium 1.
METAL: Calcium 3.
METAL: Zinc 2; via tele nitrogen; catalytic.
METAL: Zinc 1; via pros nitrogen.
METAL: Calcium 4; via carbonyl oxygen.
METAL: Zinc 1; via tele nitrogen.
METAL: Zinc 2; in inhibited form.
MOD_RES: Phosphotyrosine; by PKDCC.
MOTIF: Cysteine switch.
phobius: SIGNAL_PEPTIDE_N_REGION
phobius: SIGNAL_PEPTIDE
phobius: SIGNAL_PEPTIDE_H_REGION
phobius: SIGNAL_PEPTIDE_C_REGION
phobius: NON_CYTOPLASMIC_DOMAIN
signalp e: SignalP-noTM
InterPro GO terms
biological process
molecular function
cellular component
Panther GO terms
PTHR10201:SF151
biological process
molecular function
cellular component
- None