P05024

Sodium/potassium-transporting ATPase subunit alpha-1

UniProtKB/Swiss-Prot protein
Short nameAT1A1_PIG
Length1021 amino acids
SpeciesSus scrofa (Pig)
ProteomeUP000008227
GeneATP1A1
Function
This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium io...
Family membership
Entry matches to this protein
Feature Display Mode
Summary
Full
110211002003004005006007008009001,000
5001000
P-type_ATPase_Na-K_like
K binding site
Na binding site
Phosphorylation site
ATP-binding site
Alpha-subunit/beta-subunit interface
p-type_atpase
Probable role in phosphate transfer from ATP
Coordinates with phosphate oxygen from ATP
Mg2+ ligand
Nucleophile: attacks gamma phosphate moiety of ATP to form covalent intermediate, Mg2+ ligand
Conserved in all p-type atpases
Stabilizes transition state of phosphoryl transfer by contacting beta & gamma phosphate oxygens of ATP

InterPro GO terms

Panther GO terms
PTHR43294:SF9
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