P07333

Macrophage colony-stimulating factor 1 receptor

UniProtKB/Swiss-Prot protein
Short nameCSF1R_HUMAN
Length972 amino acids
SpeciesHomo sapiens (Human)
ProteomeUP000005640
GeneCSF1R
Function
Tyrosine-protein kinase that acts as a cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as m...
Family membership
Isoforms
Entry matches to this protein
Feature Display Mode
Summary
Full
1972100200300400500600700800900
500
IGIGIG_LIKEIgI_3_CSF-…PTKc_CSF-1RIgI_4_SCFR_…
Representative domains
IgI_4_SCFR_…
Dimer interface
PTKc_CSF-1R
ATP binding site
Polypeptide substrate binding site
Activation loop (A-loop)
Active site
CSF-1_receptor
BINDING: ATP.
NP_BIND: ATP.
DISULFID:
ACT_SITE: Proton acceptor.
PIRSR
BINDING: ATP
MOD_RES: Phosphotyrosine; by autocatalysis
NP_BIND: ATP.
BINDING: ATP
METAL: Magnesium; via carbonyl oxygen.
BINDING: ATP.
ACT_SITE: Proton acceptor.
BINDING: ATP.
NP_BIND: ATP.
METAL: Magnesium.
NP_BIND: ATP.
SITE: Important for interaction with phosphotyrosine-binding proteins.
GVLISTCMDNEQRKHFYWP*GVLISTCMDNEQRKHFYWP*

InterPro GO terms

Panther GO terms
PTHR24416:SF47
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