P07333
Macrophage colony-stimulating factor 1 receptor
UniProtKB/Swiss-Prot protein
Short name | CSF1R_HUMAN |
Length | 972 amino acids |
Species | Homo sapiens (Human) |
Proteome | UP000005640 |
Gene | CSF1R |
Function | Tyrosine-protein kinase that acts as a cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as m... |
Family membership | |
Isoforms |
Entry matches to this protein
Feature Display Mode
Summary
Full
Representative families
Representative domains
Dimer interface
ATP binding site
Polypeptide substrate binding site
Activation loop (A-loop)
Active site
BINDING: ATP.
NP_BIND: ATP.
DISULFID:
ACT_SITE: Proton acceptor.
PIRSR
BINDING: ATP
MOD_RES: Phosphotyrosine; by autocatalysis
NP_BIND: ATP.
BINDING: ATP
METAL: Magnesium; via carbonyl oxygen.
BINDING: ATP.
ACT_SITE: Proton acceptor.
BINDING: ATP.
NP_BIND: ATP.
METAL: Magnesium.
NP_BIND: ATP.
SITE: Important for interaction with phosphotyrosine-binding proteins.
phobius: SIGNAL_PEPTIDE_N_REGION
phobius: SIGNAL_PEPTIDE
phobius: SIGNAL_PEPTIDE_H_REGION
phobius: SIGNAL_PEPTIDE_C_REGION
phobius: NON_CYTOPLASMIC_DOMAIN
phobius: TRANSMEMBRANE
phobius: CYTOPLASMIC_DOMAIN
signalp e: SignalP-noTM
tmhmm: TMhelix
InterPro GO terms
biological process
molecular function
cellular component
- None
Panther GO terms
PTHR24416:SF47
biological process
- cell surface receptor protein tyrosine kinase signaling pathway (GO:0007169)
- multicellular organism development (GO:0007275)
- osteoclast differentiation (GO:0030316)
- positive regulation of cell migration (GO:0030335)
- positive regulation of kinase activity (GO:0033674)
- regulation of MAPK cascade (GO:0043408)
molecular function