P35968
Vascular endothelial growth factor receptor 2
UniProtKB/Swiss-Prot protein
Short name | VGFR2_HUMAN |
Length | 1356 amino acids |
Species | Homo sapiens (Human) |
Proteome | UP000005640 |
Gene | KDR |
Function | Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. Promotes proliferation, surv... |
Family membership | |
Isoforms |
Entry matches to this protein
Feature Display Mode
Summary
Full
Representative families
Representative domains
Active site
Activation loop (A-loop)
Polypeptide substrate binding site
ATP binding site
PIRSR
MOD_RES: Phosphotyrosine; by autocatalysis
NP_BIND: ATP.
BINDING: ATP
ACT_SITE: Proton acceptor.
BINDING: ATP.
NP_BIND: ATP.
BINDING: ATP
METAL: Magnesium; via carbonyl oxygen.
METAL: Magnesium.
NP_BIND: ATP.
phobius: SIGNAL_PEPTIDE_N_REGION
phobius: SIGNAL_PEPTIDE
phobius: SIGNAL_PEPTIDE_H_REGION
phobius: SIGNAL_PEPTIDE_C_REGION
phobius: NON_CYTOPLASMIC_DOMAIN
phobius: TRANSMEMBRANE
phobius: CYTOPLASMIC_DOMAIN
signalp e: SignalP-noTM
tmhmm: TMhelix
InterPro GO terms
biological process
molecular function
cellular component
Panther GO terms
PTHR24416:SF45
biological process
- angiogenesis (GO:0001525)
- cell surface receptor protein tyrosine kinase signaling pathway (GO:0007169)
- multicellular organism development (GO:0007275)
- cell migration (GO:0016477)
- positive regulation of cell migration (GO:0030335)
- positive regulation of kinase activity (GO:0033674)
- regulation of MAPK cascade (GO:0043408)
- endothelial cell differentiation (GO:0045446)
- positive regulation of angiogenesis (GO:0045766)
molecular function
cellular component