P35968

Vascular endothelial growth factor receptor 2

UniProtKB/Swiss-Prot protein
Short nameVGFR2_HUMAN
Length1356 amino acids
SpeciesHomo sapiens (Human)
ProteomeUP000005640
GeneKDR
Function
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. Promotes proliferation, surv...
Family membership
Isoforms
Entry matches to this protein
Feature Display Mode
Summary
Full
113561002003004005006007008009001,0001,1001,2001,300
5001000
IG_LIKEVEGFR1-…VEGF…Ig_2I-setIgI_VE…IgI_VEGFRPTKc_VEGFR2
Representative domains
PTKc_VEGFR2
Active site
Activation loop (A-loop)
Polypeptide substrate binding site
ATP binding site
PIRSR
MOD_RES: Phosphotyrosine; by autocatalysis
NP_BIND: ATP.
BINDING: ATP
ACT_SITE: Proton acceptor.
BINDING: ATP.
NP_BIND: ATP.
BINDING: ATP
METAL: Magnesium; via carbonyl oxygen.
METAL: Magnesium.
NP_BIND: ATP.
ASMRFASMRF

InterPro GO terms

Panther GO terms
PTHR24416:SF45
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