P41743

Protein kinase C iota type

UniProtKB/Swiss-Prot protein
Short nameKPCI_HUMAN
Length596 amino acids
SpeciesHomo sapiens (Human)
ProteomeUP000005640
GenePRKCI
Function
Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulat...
Family membership
Entry matches to this protein
Feature Display Mode
Summary
Full
159650100150200250300350400450500550
200400
PB1C1_aPKCSTKc_aPKC_iota
Representative domains
STKc_aPKC_iota
Polypeptide substrate binding site
Turn motif phosphorylation site
Activation loop (A-loop)
ATP binding site
Hydrophobic motif (HM)
Active site
PB1_aPKC
PB1 interaction surface
PKC_zeta
ACT_SITE: Proton acceptor.
NP_BIND: ATP.
BINDING: ATP.
PIRSR
BINDING: ATP
NP_BIND: ATP.
BINDING: ATP.
BINDING: ATP.
METAL: Magnesium; via carbonyl oxygen.
BINDING: ATP; via carbonyl oxygen.
METAL: Magnesium.
CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
ACT_SITE: Proton acceptor.
NP_BIND: ATP.
BINDING: ATP.

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